CAJ | 학술논문

MicroRNA是一类长约18～22 nt的非编码小RNA，通过促进靶mRNA降解或抑制mRNA翻译对基因的表达进行调控，影响细胞的发育、增殖、分化、凋亡等。 microRNA在肿瘤的形成发展中发挥癌基因或抑癌基因的作用，参与维持人体生理、病理活动。本文总结近年来microRNA在乳腺癌的发生、发展、早期诊断及乳腺癌转移中的作用，分析讨论microRNA在乳腺癌中的研究进展。
MicroRNA시일류장약18～22 nt적비편마소RNA，통과촉진파mRNA강해혹억제mRNA번역대기인적표체진행조공，영향세포적발육、증식、분화、조망등。 microRNA재종류적형성발전중발휘암기인혹억암기인적작용，삼여유지인체생리、병리활동。본문총결근년래microRNA재유선암적발생、발전、조기진단급유선암전이중적작용，분석토론microRNA재유선암중적연구진전。
MicroRNA is a kind of about 18 to 22 nt long, non-coding small RNA, which regulates the expression of gene by promoting mRNA deregration or inhibiting mRNA translation, influencing cell growth, pro-liferation, differentiation, apoptosis,etc.MicroRNA have the function of oncogenes or tumor suppressor in the formation and development of tumor, thus maintain normal physiological and pathological activities of human body.This review focus on the role of microRNA in the occur-rence and development, early diagnosis and metastasis of breast cancer, and summarizes current research about microRNA and breast cancer.