CAJ | 학술논문

目的研究溃疡性结肠炎(UC)患者食物不耐受状况,为指导UC患者饮食护理提供依据.方法选取2013年9月至2014年8月就诊于天津医科大学总医院UC患者47例,采取Southerland疾病活动指数(DAI)将UC患者分为缓解期组、轻度活动组和中重度活动组,采用酶联免疫吸附法(ELISA)检测UC患者及健康对照血清中食物特异性IgG抗体,与相关临床指标行统计学分析.结果 UC患者食物不耐受阳性率较高,达68.09％(32/47);不耐受阳性率最高的食物依次为鸡蛋、小麦、牛奶.缓解期组、轻度活动组和中重度活动组的患者食物不耐受阳性率分别为9/16、11/18和12/13,组间比较差异有统计学意义,x2=7.418,P＜0.05.有肠外表现组食物不耐受阳性率为11/13,显著高于无肠外表现组的55.88％(19/34),2组比较差异有统计学意义,x2=2.234,P＜0.05.性别、年龄、体质量指数、病变范围分组各组间食物不耐受阳性率比较差异均无统计学意义,P＞0.05.结论 UC患者食物不耐受阳性率高于健康人群,食物不耐受的发生与UC疾病活动度和肠外表现存在相关性,对指导UC患者饮食护理具有重要意义.
목적 연구궤양성결장염(UC)환자식물불내수상황,위지도UC환자음식호리제공의거.방법 선취2013년9월지2014년8월취진우천진의과대학총의원UC환자47례,채취Southerland질병활동지수(DAI)장UC환자분위완해기조、경도활동조화중중도활동조,채용매련면역흡부법(ELISA)검측UC환자급건강대조혈청중식물특이성IgG항체,여상관림상지표행통계학분석.결과 UC환자식물불내수양성솔교고,체68.09％(32/47);불내수양성솔최고적식물의차위계단、소맥、우내.완해기조、경도활동조화중중도활동조적환자식물불내수양성솔분별위9/16、11/18화12/13,조간비교차이유통계학의의,x2=7.418,P＜0.05.유장외표현조식물불내수양성솔위11/13,현저고우무장외표현조적55.88％(19/34),2조비교차이유통계학의의,x2=2.234,P＜0.05.성별、년령、체질량지수、병변범위분조각조간식물불내수양성솔비교차이균무통계학의의,P＞0.05.결론 UC환자식물불내수양성솔고우건강인군,식물불내수적발생여UC질병활동도화장외표현존재상관성,대지도UC환자음식호리구유중요의의.
Objective To investigate the status of food intolerance of patients with ulcerative colitis,(UC),to provide the basis for directing UC patients diet related nursing.Methods Forty-seven UC patients were selected from September 2013 to August 2014 in General Hospital of Tianjin University.The Southerland Disease Activity Index (DAI) was used to divide the UC patients into remission,mild activity and moderate to severe activity groups.The food-specific IgG antibodies status were tested by enzyme-linked immunosorbent assay in UC patients and healthy people.Relevant clinical parameters were analyzed statistically.Results Food intolerance rate in UC patients was as high as 68.08％(32/47);the food species:egg,wheat and milk ranked the most frequently intolerance food.The food intolerance rates in remission,mild activity and moderate to severe activity groups were 9/16,11/18,12/13,there were significantly different,x2=7.418,P＜0.05.Extraintestinal manifestation group had significantly higher food intolerance rate compareed to non extraintestinal manifestation group:1 1/13 vs.55.88％(19/34),x2=2.234,P＜0.05.No significant difference of food intolerance rate were showed among groups categorized according to sex,age,body mass index,site of lesion,P＞0.05.Conclusions UC patients show higher food intolerance rate than healthy people.UC disease activity and extraintestinal manifestations are correlated to food intolerance,which is of great significance to guide diet related nursing of UC patient.