CAJ | 학술논문

细菌耐药已经成为一个世界性的卫生问题，糖肽类药物替考拉宁一直作为治疗耐甲氧西林金黄色葡萄球菌的首选药物之一。替考拉宁口服不吸收，蛋白结合率高，半衰期长，大部分以原型经肾排出，肾功能不全患者半衰期延长。替考拉宁对多种革兰氏阳性菌敏感，杀菌曲线相对平缓，为非浓度依赖性，杀菌作用呈现持续效应，有明显抗生素后效应。当AUC／MIC≥345时可达到最佳治疗效果，为此，应使用负荷剂量使其快速达到有效谷浓度，同时应重视维持剂量，也可根据不同病原菌的最低抑菌浓度而选择不同的治疗方案。
세균내약이경성위일개세계성적위생문제，당태류약물체고랍저일직작위치료내갑양서림금황색포도구균적수선약물지일。체고랍저구복불흡수，단백결합솔고，반쇠기장，대부분이원형경신배출，신공능불전환자반쇠기연장。체고랍저대다충혁란씨양성균민감，살균곡선상대평완，위비농도의뢰성，살균작용정현지속효응，유명현항생소후효응。당AUC／MIC≥345시가체도최가치료효과，위차，응사용부하제량사기쾌속체도유효곡농도，동시응중시유지제량，야가근거불동병원균적최저억균농도이선택불동적치료방안。
Bacterial resistance has become a worldwide health problem, and teicoplanin has been used as one of first-choice drugs of methicillin-resistant Staphylococcus aureus (MRSA).Teicoplanin is not absorbed by oral administration, has high protein binding rate and long half-life. Most of the drug excreted in the kidneys with prototype, so that the half-life prolonged in patients with renal insufficiency.Teicoplanin, a non-concentration-dependent antibiotic which has significantly post antibi-otic effect, is sensitive against a variety of gram-positive bacteria and has a relatively flat killing curve.When the AUC /MIC≥345, teicopla-nin can achieve the best therapeutic effect.Therefore, to quickly reach an effective trough concentration, loading dose is needed and the mainte-nance dose should be paid attention to.According to the MIC against dif-ferent bacteria, a different treatment selection were also recommended.