医学检验与临床
醫學檢驗與臨床
의학검험여림상
Medical Laboratory Science and Clinics
2015年
4期
51-53
,共3页
甲胎蛋白%人绒毛膜促性腺激素%游离雌三醇%唐氏综合征
甲胎蛋白%人絨毛膜促性腺激素%遊離雌三醇%唐氏綜閤徵
갑태단백%인융모막촉성선격소%유리자삼순%당씨종합정
AFP%Beta-HCG%Free Estriol%Down's syndrome
目的：探讨分析孕中血清中甲胎蛋白（AFP）、人绒毛膜促性腺激素（beta-HCG）及游离雌三醇（uE3）的检测对唐氏综合征筛查的临床意义。方法：从2009年10月到2013年1月期间来我院检查的980例孕中期妇女进行AFP、beta-HCG及uE3三项指标检测，结合孕妇的年龄、体重、孕周等因素，对于高风险的孕妇再进一步行B超或羊水细胞染色体进行确诊，观察不同年龄孕妇所产婴儿唐氏综合征的发生情况。结果：980例孕中期孕妇通过血清AFP、beta-HCG及uE3的检测，筛查唐氏综合征高风险52例(5.3%)，经B超或羊水细胞染色体进行确诊唐氏综合征12例；35岁以上的孕妇唐氏综合征阳性风险率显著高于35岁以下的孕妇，差异具有统计学（P<0.05）。结论：孕中期检测血清中AFP、beta-HCG和uE3能够有效筛查出唐氏综合征阳性高风险孕妇，降低了唐氏综合征患儿的出生率，对于优生工作起到极大的辅助作用。
目的：探討分析孕中血清中甲胎蛋白（AFP）、人絨毛膜促性腺激素（beta-HCG）及遊離雌三醇（uE3）的檢測對唐氏綜閤徵篩查的臨床意義。方法：從2009年10月到2013年1月期間來我院檢查的980例孕中期婦女進行AFP、beta-HCG及uE3三項指標檢測，結閤孕婦的年齡、體重、孕週等因素，對于高風險的孕婦再進一步行B超或羊水細胞染色體進行確診，觀察不同年齡孕婦所產嬰兒唐氏綜閤徵的髮生情況。結果：980例孕中期孕婦通過血清AFP、beta-HCG及uE3的檢測，篩查唐氏綜閤徵高風險52例(5.3%)，經B超或羊水細胞染色體進行確診唐氏綜閤徵12例；35歲以上的孕婦唐氏綜閤徵暘性風險率顯著高于35歲以下的孕婦，差異具有統計學（P<0.05）。結論：孕中期檢測血清中AFP、beta-HCG和uE3能夠有效篩查齣唐氏綜閤徵暘性高風險孕婦，降低瞭唐氏綜閤徵患兒的齣生率，對于優生工作起到極大的輔助作用。
목적：탐토분석잉중혈청중갑태단백（AFP）、인융모막촉성선격소（beta-HCG）급유리자삼순（uE3）적검측대당씨종합정사사적림상의의。방법：종2009년10월도2013년1월기간래아원검사적980례잉중기부녀진행AFP、beta-HCG급uE3삼항지표검측，결합잉부적년령、체중、잉주등인소，대우고풍험적잉부재진일보행B초혹양수세포염색체진행학진，관찰불동년령잉부소산영인당씨종합정적발생정황。결과：980례잉중기잉부통과혈청AFP、beta-HCG급uE3적검측，사사당씨종합정고풍험52례(5.3%)，경B초혹양수세포염색체진행학진당씨종합정12례；35세이상적잉부당씨종합정양성풍험솔현저고우35세이하적잉부，차이구유통계학（P<0.05）。결론：잉중기검측혈청중AFP、beta-HCG화uE3능구유효사사출당씨종합정양성고풍험잉부，강저료당씨종합정환인적출생솔，대우우생공작기도겁대적보조작용。
Objective:To explore the clinical significance of detecting serum α-fetoprotein (AFP) , human chorionic gonadotropin (beta HCG) and free estriol (uE3) in second trimester to screening Down’s syndrome. Methods:We detected the three indicators, serum AFP, beta - HCG and uE3, for the 980 pregnant women who had their check-ups in our hospital from October 2009 to January 2013. Combined with factors such as age, weight and gestational age, high-risk cases were further confirmed by ultrasonography or amniotic fluid cells chromosome. The purpose was to observe the occurrence of Down's syndrome in babies delivered by pregnant women at different ages.Results:Among the 980 pregnant women who went through the serum AFP, beta - HCG and uE3 detection in second trimester, 52 cases (5.3%) were at high risk of Down's syndrome and 12 cases were confirmed by ultrasonography or amniotic fluid cells chromosome. It is apparent that pregnant women over 35 years old suffer higher risk of Down's syndrome than those under the age of 35. The difference was statistically significant(P<0.05). Conclusions:The detection of serum AFP, beta HCG and uE3 in second trimester can effectively screen pregnant women at high risk of Down's syndrome and reduce the birth rate of babies with Down's syndrome, which plays a helpful role in assisting the eugenic work.
