医学检验与临床
醫學檢驗與臨床
의학검험여림상
Medical Laboratory Science and Clinics
2015年
4期
35-37,50
,共4页
冠心病%血清同型半胱氨酸%血脂%相关性%心脏功能
冠心病%血清同型半胱氨痠%血脂%相關性%心髒功能
관심병%혈청동형반광안산%혈지%상관성%심장공능
Coronary heart disease%Homocysteine%Blood lipid%Correlation%Cardiac function
目的：探讨血清同型半胱氨酸与血脂水平在冠心病风险的相关性及相关功能研究。方法：选择2012年5月至2014年5月期间我院心内科收治的116例诊断为CHD的患者作为研究组，选取同时期前往我院进行健康检查的100例健康人群作为对照组，检测两组研究对象的血清Hcy及血脂水平，并分析Hcy及血脂水平对CHD的诊断价值、灵敏性及特异性以及在不同类型冠心病中的差异。结果：研究组的Hcy、TG、Lp（a）的水平均显著高于对照组，而HDL-C水平要明显低于对照组，差异均具有统计学意义（P<0.05），而TC、LDL-C水平比较无显著性差异（P>0.05）；其中Hcy的AUC面积最大，且Hcy及HDL-C水平比较差异无统计学意义（P>0.05），其余指标均具有统计学意义（P<0.05）；而HDL-C对冠心病诊断的灵敏性最高，Hcy具有较高的特异性，而TC、LDL-C及Lp（a）的诊断灵敏性均较低；不同冠心病类型组间TC、HDL-C、LDL-C的指标比较无显著性差异（P>0.05），而Hcy、TG、Lp（a）水平均具有显著性差异，三种类型的冠心病的指标均明显高于对照组，差异均具有统计学意义（P<0.05）。结论：血清Hcy水平升高以及HDL-C水平降低均为CHD患者的相关危险因素，能够为CHD的预防、诊断及治疗提供依据。
目的：探討血清同型半胱氨痠與血脂水平在冠心病風險的相關性及相關功能研究。方法：選擇2012年5月至2014年5月期間我院心內科收治的116例診斷為CHD的患者作為研究組，選取同時期前往我院進行健康檢查的100例健康人群作為對照組，檢測兩組研究對象的血清Hcy及血脂水平，併分析Hcy及血脂水平對CHD的診斷價值、靈敏性及特異性以及在不同類型冠心病中的差異。結果：研究組的Hcy、TG、Lp（a）的水平均顯著高于對照組，而HDL-C水平要明顯低于對照組，差異均具有統計學意義（P<0.05），而TC、LDL-C水平比較無顯著性差異（P>0.05）；其中Hcy的AUC麵積最大，且Hcy及HDL-C水平比較差異無統計學意義（P>0.05），其餘指標均具有統計學意義（P<0.05）；而HDL-C對冠心病診斷的靈敏性最高，Hcy具有較高的特異性，而TC、LDL-C及Lp（a）的診斷靈敏性均較低；不同冠心病類型組間TC、HDL-C、LDL-C的指標比較無顯著性差異（P>0.05），而Hcy、TG、Lp（a）水平均具有顯著性差異，三種類型的冠心病的指標均明顯高于對照組，差異均具有統計學意義（P<0.05）。結論：血清Hcy水平升高以及HDL-C水平降低均為CHD患者的相關危險因素，能夠為CHD的預防、診斷及治療提供依據。
목적：탐토혈청동형반광안산여혈지수평재관심병풍험적상관성급상관공능연구。방법：선택2012년5월지2014년5월기간아원심내과수치적116례진단위CHD적환자작위연구조，선취동시기전왕아원진행건강검사적100례건강인군작위대조조，검측량조연구대상적혈청Hcy급혈지수평，병분석Hcy급혈지수평대CHD적진단개치、령민성급특이성이급재불동류형관심병중적차이。결과：연구조적Hcy、TG、Lp（a）적수평균현저고우대조조，이HDL-C수평요명현저우대조조，차이균구유통계학의의（P<0.05），이TC、LDL-C수평비교무현저성차이（P>0.05）；기중Hcy적AUC면적최대，차Hcy급HDL-C수평비교차이무통계학의의（P>0.05），기여지표균구유통계학의의（P<0.05）；이HDL-C대관심병진단적령민성최고，Hcy구유교고적특이성，이TC、LDL-C급Lp（a）적진단령민성균교저；불동관심병류형조간TC、HDL-C、LDL-C적지표비교무현저성차이（P>0.05），이Hcy、TG、Lp（a）수평균구유현저성차이，삼충류형적관심병적지표균명현고우대조조，차이균구유통계학의의（P<0.05）。결론：혈청Hcy수평승고이급HDL-C수평강저균위CHD환자적상관위험인소，능구위CHD적예방、진단급치료제공의거。
Objective:To investigate the correlation between serum homocysteine and blood lipid level in patients with coronary heart disease risk and to research the related functions. Methods:During the period of 2012 May to 2014 May, selected 116 cases in our hospital were admitted to Department of Cardiology diagnosis for CHD patients as research group, 100 healthy people selected from the same period to our hospital health examination as the control group, serum Hcy and serum lipid levels in two groups were detected the object of study, and analysis of blood lipids and the level of Hcy in the diagnosis of CHD value and the sensitivity and specificity and in different types of coronary heart disease differences.Results:Research group of Hcy, TG, Lp (a) levels were significantly higher than those in control group, while the HDL-C level was significantly lower than that in control group, the difference was statistically significant (P<0.05), but no significant difference compared with TC, the level of LDL-C (P>0.05); wherein Hcy AUC the largest area, no statistical significance and comparison of Hcy and HDL-C level difference (P>0.05), the other indexes with statistical significance (P<0.05); while the HDL-C on the sensitivity of the diagnosis of coronary heart disease is the highest, the specificity of Hcy is high, while TC, LDL-C and Lp (a) in the diagnosis of sensitivity are low; and there is no significant difference in different kinds of coronary heart disease between groups TC, HDL-C, the LDL-C index (P>0.05), while Hcy, TG, Lp (a) levels were significant differences, coronary heart disease, three types of index were significantly higher than those in control group, the difference was statistically significant (P<0.05). Conclusions:Elevated levels of serum Hcy and HDL-C level reduced are related risk factors of patients with CHD, the combined detection of serum Hcy and serum lipids by has the high value of CHD, which can provide the basis for prevention, diagnosis and treatment of CHD.
