中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
Chinese Journal of Woman and Child Health Research
2015年
4期
863-865
,共3页
人乳头状瘤病毒感染%基层妇女%宫颈病变筛查%应用价值
人乳頭狀瘤病毒感染%基層婦女%宮頸病變篩查%應用價值
인유두상류병독감염%기층부녀%궁경병변사사%응용개치
HPV infection%grass-root women%cervical lesions screening%application value
目的 评价人乳头状瘤病毒( HPV)感染检测在基层妇女宫颈病变筛查中的应用价值. 方法 选择2012年5月至2014年4月期间在永嘉县人民医院妇产科及永嘉县妇保院进行妇科检查的630例宫颈疾病妇女为研究对象,同时进行薄层液基细胞学( TCT)及高危型HPV-DNA检测,并对TCT及HPV-DNA阳性者在阴道镜下取多点宫颈组织进行活检,以病理诊断结果作为金标准,比较两种检测方法在基层妇女宫颈病变筛查中的应用效果,观察不同年龄段妇女HPV感染分布情况. 结果 在630例患者中,HPV-DNA阳性率为30.32%,TCT阳性率为28.09%,两种检测方法阳性率比较差异无统计学意义(χ2 =0.752, P>0.05);但HPV-DNA检测敏感度及特异度均稍高于TCT检测方法,两种方法联合检测能够将敏感度及特异度进一步提高.HPV-DNA阳性者中,≥30岁妇女感染率为64.92%,显著高于30岁以下者的34.83%(χ2 =34.020,P<0.01). 结论 宫颈病变妇女HPV-DNA阳性率较高,在TCT基础上,联合HPV感染检测有助于宫颈病变性质的进一步筛查,对于30岁以上的妇女更具检测价值.
目的 評價人乳頭狀瘤病毒( HPV)感染檢測在基層婦女宮頸病變篩查中的應用價值. 方法 選擇2012年5月至2014年4月期間在永嘉縣人民醫院婦產科及永嘉縣婦保院進行婦科檢查的630例宮頸疾病婦女為研究對象,同時進行薄層液基細胞學( TCT)及高危型HPV-DNA檢測,併對TCT及HPV-DNA暘性者在陰道鏡下取多點宮頸組織進行活檢,以病理診斷結果作為金標準,比較兩種檢測方法在基層婦女宮頸病變篩查中的應用效果,觀察不同年齡段婦女HPV感染分佈情況. 結果 在630例患者中,HPV-DNA暘性率為30.32%,TCT暘性率為28.09%,兩種檢測方法暘性率比較差異無統計學意義(χ2 =0.752, P>0.05);但HPV-DNA檢測敏感度及特異度均稍高于TCT檢測方法,兩種方法聯閤檢測能夠將敏感度及特異度進一步提高.HPV-DNA暘性者中,≥30歲婦女感染率為64.92%,顯著高于30歲以下者的34.83%(χ2 =34.020,P<0.01). 結論 宮頸病變婦女HPV-DNA暘性率較高,在TCT基礎上,聯閤HPV感染檢測有助于宮頸病變性質的進一步篩查,對于30歲以上的婦女更具檢測價值.
목적 평개인유두상류병독( HPV)감염검측재기층부녀궁경병변사사중적응용개치. 방법 선택2012년5월지2014년4월기간재영가현인민의원부산과급영가현부보원진행부과검사적630례궁경질병부녀위연구대상,동시진행박층액기세포학( TCT)급고위형HPV-DNA검측,병대TCT급HPV-DNA양성자재음도경하취다점궁경조직진행활검,이병리진단결과작위금표준,비교량충검측방법재기층부녀궁경병변사사중적응용효과,관찰불동년령단부녀HPV감염분포정황. 결과 재630례환자중,HPV-DNA양성솔위30.32%,TCT양성솔위28.09%,량충검측방법양성솔비교차이무통계학의의(χ2 =0.752, P>0.05);단HPV-DNA검측민감도급특이도균초고우TCT검측방법,량충방법연합검측능구장민감도급특이도진일보제고.HPV-DNA양성자중,≥30세부녀감염솔위64.92%,현저고우30세이하자적34.83%(χ2 =34.020,P<0.01). 결론 궁경병변부녀HPV-DNA양성솔교고,재TCT기출상,연합HPV감염검측유조우궁경병변성질적진일보사사,대우30세이상적부녀경구검측개치.
Objective To evaluate the application value of detecting human papilloma virus ( HPV ) infection in screening of cervical lesions of grass-root women.Methods During the period of May 2012 to April 2014, 630 women with cervical diseases examined in obstetrics and gynecology department of People' s Hospital of Yongjia County and Maternity Hospital of Yongjia County were recruited in the research, and they undertook ThinPrep cytology test ( TCT) and high risk HPV-DNA testing, and biopsy was done for cases with TCT and HPV-DNA positive results.Pathology results were taken as gold standard.Application effects of two methods were compared and HPV infection was observed among women at different ages.Results Among 630 patients, the positive rate of HPV-DNA was 30.32%and the positive rate of TCT was 28.09%.There was no significant difference in positive rate of two methods (χ2 =0.752,P>0.05).But the sensitivity and specificity of HPV-DNA detection method were slightly higher than those of TCT detection method, and the combined detection with two methods could further improve the sensitivity and specificity.Among HPV-DNA positive subjects, infection rate of women≥30 was 64.92%, which was significantly higher than that of women below 30 (34.83%) (χ2 =34.020,P<0.01).Conclusion HPV-DNA positive rate is high among women with cervical lesions.Combining TCT with HPV detection is helpful for screening cervical lesions, which is more valuable for women over 30.
