CAJ | 학술논문

目的：探讨川芎嗪注射液治疗老年冠心病心绞痛的临床疗效及其对血液流变学的影响。方法选取2012年5月—2014年5月在安庆市立医院就诊的老年冠心病心绞痛患者72例，按随机数字表法分为对照组与观察组，各36例。对照组患者给予常规治疗，观察组患者在常规治疗基础上加用川芎嗪注射液治疗，两组患者均以10 d为1个疗程，共治疗2个疗程。比较两组患者临床疗效及治疗前后心绞痛症状、血液流变学指标、血脂指标，记录治疗期间不良反应情况，其中血液流变学指标包括血浆黏度、全血黏度、纤维蛋白原、红细胞聚集指数及红细胞比容，心绞痛症状包括心绞痛发作持续时间、发作次数，血脂指标包括低密度脂蛋白胆固醇（ LDL－C）、总胆固醇（ TC）、高密度脂蛋白胆固醇（HDL－C）、三酰甘油（TG）。结果观察组患者临床疗效优于对照组（u＝－2.008， P＝0.045）。治疗前两组患者心绞痛发作持续时间、发作次数比较，差异无统计学意义（ P＞0.05）；治疗后观察组患者心绞痛发作持续时间短于对照组、发作次数少于对照组（ P＜0.05）。治疗前两组患者血浆黏度、全血黏度、纤维蛋白原、红细胞聚集指数及治疗前后红细胞比容比较，差异无统计学意义（ P＞0.05）；治疗后观察组患者血浆黏度、全血黏度、纤维蛋白原及红细胞聚集指数低于对照组（ P＜0.05）。治疗前两组患者LDL－C、 TG、 TC及治疗前后HDL－C水平比较，差异无统计学意义（P＞0.05）；治疗后观察组患者LDL－C、 TG及TC水平低于对照组（P＜0.05）。治疗期间两组患者均未出现明显药物不良反应。结论川芎嗪注射液治疗老年冠心病心绞痛的临床疗效确切，能有效改善患者心绞痛症状、血液流变学及血脂异常情况，且安全性较高。
목적：탐토천궁진주사액치료노년관심병심교통적림상료효급기대혈액류변학적영향。방법선취2012년5월—2014년5월재안경시립의원취진적노년관심병심교통환자72례，안수궤수자표법분위대조조여관찰조，각36례。대조조환자급여상규치료，관찰조환자재상규치료기출상가용천궁진주사액치료，량조환자균이10 d위1개료정，공치료2개료정。비교량조환자림상료효급치료전후심교통증상、혈액류변학지표、혈지지표，기록치료기간불량반응정황，기중혈액류변학지표포괄혈장점도、전혈점도、섬유단백원、홍세포취집지수급홍세포비용，심교통증상포괄심교통발작지속시간、발작차수，혈지지표포괄저밀도지단백담고순（ LDL－C）、총담고순（ TC）、고밀도지단백담고순（HDL－C）、삼선감유（TG）。결과관찰조환자림상료효우우대조조（u＝－2.008， P＝0.045）。치료전량조환자심교통발작지속시간、발작차수비교，차이무통계학의의（ P＞0.05）；치료후관찰조환자심교통발작지속시간단우대조조、발작차수소우대조조（ P＜0.05）。치료전량조환자혈장점도、전혈점도、섬유단백원、홍세포취집지수급치료전후홍세포비용비교，차이무통계학의의（ P＞0.05）；치료후관찰조환자혈장점도、전혈점도、섬유단백원급홍세포취집지수저우대조조（ P＜0.05）。치료전량조환자LDL－C、 TG、 TC급치료전후HDL－C수평비교，차이무통계학의의（P＞0.05）；치료후관찰조환자LDL－C、 TG급TC수평저우대조조（P＜0.05）。치료기간량조환자균미출현명현약물불량반응。결론천궁진주사액치료노년관심병심교통적림상료효학절，능유효개선환자심교통증상、혈액류변학급혈지이상정황，차안전성교고。
Objective To investigate the clinical effect of ligustrazine injection on angina pectoris and its impact on hemorheology in aged patients with coronary heart disease.Methods From May 2012 to May 2014, a total of 72 aged coronary heart disease patients with angina pectoris were selected in Anqing Municipal Hospital, and they were divided into control group and observation group according to random number table, each of 36 cases.Patients of control group were given conventional treatment, while patients of observation group were given extra ligustrazine injection based on conventional treatment, both groups treated for 2 courses (10 days as a course).Clinical effect, angina pectoris symptom (including attack duration and attack frequency of angina pectoris) , hemodynamic index ( including plasma viscosity, whole blood viscosity, fibrinogen, erythrocyte aggregation index and hematocrit) , blood lipids index ( including LDL-C, TC, HDL-C and TG) before and after treatment were compared between the two groups, incidence of adverse reactions was recorded during treatment.Results The clinical effect of observation group was statistically significantly better than that of control group ( u =-2.008, P =0.045).No statistically significant differences of attack duration or attack frequency of angina pectoris was found between the two groups before treatment ( P>0.05) , while attack duration of angina pectoris of observation group was statistically significantly shorter than that of control group after treatment, attack frequency of angina pectoris of observation group was statistically significantly less than that of control group after treatment ( P <0.05 ) . No statistically significant differences of plasma viscosity, whole blood viscosity, fibrinogen, erythrocyte aggregation index or hematocrit was found between the two groups before treatment ( P >0.05), while above index (except for hematocrit) of observation group were statistically significantly lower than those of control group after treatment (P<0.05).No statistically significant differences of LDL-C, TC, HDL-C or TG was found between the two groups before treatment (P>0.05), while above index (except for HDL-C) of observation group were statistically significantly lower than those of control group after treatment (P<0.05).No one of the two groups occurred any obvious adverse reactions during treatment.Conclusion Ligustrazine injection has certain clinical effect on angina pectoris in aged patients with coronary heart disease, which can effectively relieve the angina pectoris symptom, improve the hemorheology and dyslipidemia, is with high safety.