CAJ | 학술논문

目的：观察齐拉西酮与利培酮对精神分裂症患者的治疗效果及其对血糖、血脂的影响。方法将96例精神分裂症患者随机分为采用齐拉西酮治疗的齐拉西酮组与采用利培酮治疗的利培酮组，共治疗8周，于基线水平（治疗前）、治疗第4周末和第8周末分别对患者的血糖、血脂进行测定。结果两组治疗前阳性和阴性症状量表（PANSS）阳性症状评分、阴性症状评分比较，差异无统计学意义（P＞0．05）。两组治疗第4、8周评分与基线评分比较均显著下降，差异均有统计学意义（P＜0．05），而两组间比较差异无统计学意义（ P＞0．05）。治疗8周后，齐拉西酮组有效率为91．7％，利培酮组有效率为89．6％，两组间比较差异无统计学意义（P＞0．05）。齐拉西酮组治疗后血脂、血糖水平与基线水平比较差异无统计学意义（P＞0．05）。利培酮组治疗后血脂、血糖水平增加明显，与基线水平比较差异有统计学意义（P＜0．05）。结论齐拉西酮与利培酮治疗精神分裂症疗效相当。齐拉西酮对精神分裂症患者的血糖、血脂无明显影响，而利培酮可升高血糖、血脂，长期服用需注意其副作用。
목적：관찰제랍서동여리배동대정신분렬증환자적치료효과급기대혈당、혈지적영향。방법장96례정신분렬증환자수궤분위채용제랍서동치료적제랍서동조여채용리배동치료적리배동조，공치료8주，우기선수평（치료전）、치료제4주말화제8주말분별대환자적혈당、혈지진행측정。결과량조치료전양성화음성증상량표（PANSS）양성증상평분、음성증상평분비교，차이무통계학의의（P＞0．05）。량조치료제4、8주평분여기선평분비교균현저하강，차이균유통계학의의（P＜0．05），이량조간비교차이무통계학의의（ P＞0．05）。치료8주후，제랍서동조유효솔위91．7％，리배동조유효솔위89．6％，량조간비교차이무통계학의의（P＞0．05）。제랍서동조치료후혈지、혈당수평여기선수평비교차이무통계학의의（P＞0．05）。리배동조치료후혈지、혈당수평증가명현，여기선수평비교차이유통계학의의（P＜0．05）。결론제랍서동여리배동치료정신분렬증료효상당。제랍서동대정신분렬증환자적혈당、혈지무명현영향，이리배동가승고혈당、혈지，장기복용수주의기부작용。
Objective To observe the effects of ziprasidone and risperidone on patients with schizophrenia and their influence on bloodglucoseandlipids.Methods 96patientswithschizophrenicenrolledinthestudywererandomlydividedintotwogroups,zi‐prasidone and risperidone group ,and both were treated for 8 weeks .Their blood glucose ,blood lipid of base line and at the end of the 4th ,8th week were determined respectively .Results The positive and negative symptoms scores of the two groups by using Positive and Negative Syndrome Scale(PANSS) before and after treatment were not statistically different(P> 0 .05) .Compared with the baseline scores ,scores at the end of 4th and 8th week in both ziprasidone and risperidone groups significantly decreased(P<0 .05) ,but there was no statistically significant difference between the two groups(P>0 .05) .After 8 weeks′ treatment ,the ef‐fective rate was 91 .7% in ziprasidone groups and 89 .6% in risperidone group .There were no significant differences between the two groups(P>0 .05) .The blood lipids and glucose levels were less increased after ziprasidone treatment ,but was not statistically significant(P>0 .05) .The blood lipids and glucose levels significantly increased after risperidone treatment(P<0 .05) .Conclusion Ziprasidone and risperidone had the same effect on schizophrenia .Ziprasidone had no effect on blood glucose and lipids in schizo‐phrenic patients ,while risperidone could increase blood glucose and lipids level ,we should pay attention to the side effects of long‐term use .