中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
Chinese Journal of Woman and Child Health Research
2015年
4期
692-694
,共3页
妊娠期高血压疾病%促血管生成素-2%胎儿%脐血
妊娠期高血壓疾病%促血管生成素-2%胎兒%臍血
임신기고혈압질병%촉혈관생성소-2%태인%제혈
hypertensive disorder complicating pregnancy (HDCP)%angiopoietin-2 (Ang-2)%fetus%umbilical cord blood
目的 检测妊娠期高血压疾病患者及其胎儿脐血血清中促血管生成素-2(Ang-2)的水平,以探讨Ang-2在妊娠期高血压疾病发病中的作用. 方法 采用酶联免疫吸附技术( ELISA)测定150例妊娠期高血压疾病患者,50例正常妊娠妇女及其胎儿脐血血清中Ang-2水平,并对数据进行分析. 结果 妊娠期高血压疾病患者中,血清Ang-2水平在妊娠期高血压组为(19.57 ± 1.51)μg/L,轻度子痫前期组为(14.93 ±2.87)μg/L,重度子痫前期组为(10.85 ±1.45)μg/L,均明显低于对照组(22.79 ±2.93)μg/L,经比较有极显著性差异(t值分别为2.013、2.246、2.861,均P<0.05). 妊娠期高血压疾病新生儿中,脐血血清Ang-2水平在妊娠期高血压组为(21.43 ±1.21)μg/L,轻度子痫前期组为(17.55 ±1.67)μg/L,重度子痫前期组为(13.84 ±1.29)μg/L,均显著低于对照组(25.76 ±2.83)μg/L,经比较有极显著性差异(t值分别为2.253、2.391、2.682,均P<0.05). 结论 孕妇血清中Ang-2水平与妊娠期高血压疾病的发病及病情轻重有关,而脐血血清中Ang-2与孕妇血清Ang-2水平一致.
目的 檢測妊娠期高血壓疾病患者及其胎兒臍血血清中促血管生成素-2(Ang-2)的水平,以探討Ang-2在妊娠期高血壓疾病髮病中的作用. 方法 採用酶聯免疫吸附技術( ELISA)測定150例妊娠期高血壓疾病患者,50例正常妊娠婦女及其胎兒臍血血清中Ang-2水平,併對數據進行分析. 結果 妊娠期高血壓疾病患者中,血清Ang-2水平在妊娠期高血壓組為(19.57 ± 1.51)μg/L,輕度子癇前期組為(14.93 ±2.87)μg/L,重度子癇前期組為(10.85 ±1.45)μg/L,均明顯低于對照組(22.79 ±2.93)μg/L,經比較有極顯著性差異(t值分彆為2.013、2.246、2.861,均P<0.05). 妊娠期高血壓疾病新生兒中,臍血血清Ang-2水平在妊娠期高血壓組為(21.43 ±1.21)μg/L,輕度子癇前期組為(17.55 ±1.67)μg/L,重度子癇前期組為(13.84 ±1.29)μg/L,均顯著低于對照組(25.76 ±2.83)μg/L,經比較有極顯著性差異(t值分彆為2.253、2.391、2.682,均P<0.05). 結論 孕婦血清中Ang-2水平與妊娠期高血壓疾病的髮病及病情輕重有關,而臍血血清中Ang-2與孕婦血清Ang-2水平一緻.
목적 검측임신기고혈압질병환자급기태인제혈혈청중촉혈관생성소-2(Ang-2)적수평,이탐토Ang-2재임신기고혈압질병발병중적작용. 방법 채용매련면역흡부기술( ELISA)측정150례임신기고혈압질병환자,50례정상임신부녀급기태인제혈혈청중Ang-2수평,병대수거진행분석. 결과 임신기고혈압질병환자중,혈청Ang-2수평재임신기고혈압조위(19.57 ± 1.51)μg/L,경도자간전기조위(14.93 ±2.87)μg/L,중도자간전기조위(10.85 ±1.45)μg/L,균명현저우대조조(22.79 ±2.93)μg/L,경비교유겁현저성차이(t치분별위2.013、2.246、2.861,균P<0.05). 임신기고혈압질병신생인중,제혈혈청Ang-2수평재임신기고혈압조위(21.43 ±1.21)μg/L,경도자간전기조위(17.55 ±1.67)μg/L,중도자간전기조위(13.84 ±1.29)μg/L,균현저저우대조조(25.76 ±2.83)μg/L,경비교유겁현저성차이(t치분별위2.253、2.391、2.682,균P<0.05). 결론 잉부혈청중Ang-2수평여임신기고혈압질병적발병급병정경중유관,이제혈혈청중Ang-2여잉부혈청Ang-2수평일치.
Objective To detect the levels of angiopoietin -2 ( Ang-2 ) in serum of patients with hypertensive disorder complicating pregnancy ( HDCP) and umbilical cord blood of their fetuses, so as to explore the role of Ang-2 in pathogenesis of the disease.Methods Enzyme linked immunosorbent assay ( ELISA) was used to measure serum Ang-2 levels in 150 patients with HDCP and 50 normal pregnant women and those in their fetal umbilical cord.Results Ang-2 level in HDCP group ( gestational hypertension group:19.57 ±1.51μg/L;mild preeclampsia group:14.93 ±2.87μg/L;severe preeclampsia group:10.85 ±1.45μg/L) was significantly lower than that (22.79 ± 2.93μg/L) in normal pregnant group (t value was 2.013, 2.246 and 2.861, respectively, all P<0.05).There was also difference in serum level of Ang-2 in umbilical cord between HDCP group ( gestational hypertension group: 21.43 ±1.21μg/L;mild preeclampsia group:17.55 ±1.67μg/L;severe preeclampsia group:13.84 ±1.29μg/L) and the control group (25.76 ±2.83μg/L), and the difference was significant ( t value was 2.253, 2.391 and 2.682, respectively, all P<0.05) .Conclusion The levels of Ang-2 in pregnant women are correlated with the pathogenesis and severity of HDCP, and they are in accordance with those in umbilical cord.
