CAJ | 학술논문

目的：探讨婴儿（＜1岁）急性下呼吸道合胞病毒感染的临床流行病学特点及其危险因素。方法选取深圳市宝安区沙井人民医院2013年4月—2014年4月收治的＜1岁急性下呼吸道感染患儿1831例，回顾性分析其临床资料，危险因素的分析采用多因素Logistic回归分析。结果1831例患儿中974例（占53.19％）为合胞病毒感染，合胞病毒感染患儿各季节检出率从高到低依次为冬季61.27％（519／847）、秋季50.63％（201／397）、春季44.58％（140／314）、夏季41.75％（114／273），冬季检出率高于夏季和春季（P＜0.05）。多因素Logistic回归分析结果显示，秋季发病〔OR＝3.445，95％CI （0.681，3.546）〕、冬季发病〔OR＝3.952，95％CI （1.586，4.039）〕、合并先天性心脏病〔OR＝2.452，95％CI （0.271，3.308）〕、母亲特应性疾病〔OR＝3.358，95％CI （1.321，3.394）〕、早产儿〔OR＝3.041，95％CI （1.388，4.328）〕及家庭月收入＜5000元〔OR＝1.442，95％CI （1.138，4.283）〕是婴儿（＜1岁）发生急性下呼吸道合胞病毒感染的独立危险因素（ P＜0.05）。结论婴儿（＜1岁）急性下呼吸道合胞病毒感染发病率较高，且秋季和冬季为其高发季节，应加强病情监控。此外，秋季发病、冬季发病、合并先天性心脏病、母亲特应性疾病、早产儿及家庭月收入＜5000元是婴儿（＜1岁）发生急性下呼吸道合胞病毒感染的独立危险因素，对合并以上因素的婴儿（＜1岁）应给予高度重视，以降低合胞病毒感染风险。
목적：탐토영인（＜1세）급성하호흡도합포병독감염적림상류행병학특점급기위험인소。방법선취심수시보안구사정인민의원2013년4월—2014년4월수치적＜1세급성하호흡도감염환인1831례，회고성분석기림상자료，위험인소적분석채용다인소Logistic회귀분석。결과1831례환인중974례（점53.19％）위합포병독감염，합포병독감염환인각계절검출솔종고도저의차위동계61.27％（519／847）、추계50.63％（201／397）、춘계44.58％（140／314）、하계41.75％（114／273），동계검출솔고우하계화춘계（P＜0.05）。다인소Logistic회귀분석결과현시，추계발병〔OR＝3.445，95％CI （0.681，3.546）〕、동계발병〔OR＝3.952，95％CI （1.586，4.039）〕、합병선천성심장병〔OR＝2.452，95％CI （0.271，3.308）〕、모친특응성질병〔OR＝3.358，95％CI （1.321，3.394）〕、조산인〔OR＝3.041，95％CI （1.388，4.328）〕급가정월수입＜5000원〔OR＝1.442，95％CI （1.138，4.283）〕시영인（＜1세）발생급성하호흡도합포병독감염적독립위험인소（ P＜0.05）。결론영인（＜1세）급성하호흡도합포병독감염발병솔교고，차추계화동계위기고발계절，응가강병정감공。차외，추계발병、동계발병、합병선천성심장병、모친특응성질병、조산인급가정월수입＜5000원시영인（＜1세）발생급성하호흡도합포병독감염적독립위험인소，대합병이상인소적영인（＜1세）응급여고도중시，이강저합포병독감염풍험。
Objective To analyze the clinical epidemiological characteristics and risk factors of acute lower respiratory syncytial virus infection in infants below 1 year old.Methods From April 2013 to April 2014, a total of 1 831 infants (below 1 year old) with acute lower respiratory tract infection were enrolled in Shajing People′s Hospital of Baoan District, Shenzhen and their clinical data was retrospectively analyzed, multivariate Logistic regression analysis was used to analyze the risk factors. Results Out of the 1 831 infants, 974 cases found syncytial virus infection, accounted for 53.19%.Seasonable distribution:winter of 61.27% (519/847), autumn of 50.63% (201/397), spring of 44.58% (140/314), summer of 41.75% (114/273), the morbidity of acute lower respiratory syncytial virus infection in winter was statistically significantly higher than that in summer and spring, respectively (P<0.05).Multivariate Logistic regression analysis showed that, attack in autumn 〔OR=3.445, 95%CI (0.681, 3.546)〕, attack in winter 〔OR=3.952, 95%CI (1.586, 4.039)〕, congenital heart disease〔OR=2.452, 95%CI (0.271, 3.308)〕, mother′s atopic disease 〔OR=3.358, 95%CI (1.321, 3.394)〕, premature delivery 〔OR=3.041, 95%CI (1.388, 4.328)〕 and family′s month-earning less than 5 000 yuan 〔OR=1.442, 95%CI (1.138, 4.283)〕 were risk factors of acute lower respiratory syncytial virus infection in infants below 1 year old (P<0.05). Conclusion The morbidity of acute lower respiratory syncytial virus infection is high in infants below 1 year old, autumn and winter were the high -occurrence seasons; attack in autumn, attack in winter, congenital heart disease, mother′s atopic disease, premature delivery and family′s month-earning less than 5 000 yuan are risk factors of acute lower respiratory syncytial virus infection in infants below 1 year old, infants with above risk factors should be pay more attentions to, to reduce the onset risk of syncytial virus infection.