医学综述
醫學綜述
의학종술
Medical Recapitulate
2015年
16期
2935-2938
,共4页
徐丰博(综述)%孙懿(审校)
徐豐博(綜述)%孫懿(審校)
서봉박(종술)%손의(심교)
骨髓瘤管型肾病%高截留量血液透析%游离轻链
骨髓瘤管型腎病%高截留量血液透析%遊離輕鏈
골수류관형신병%고절류량혈액투석%유리경련
Myeloma cast nephropathy%High cut-off hemodialysis%Free light chain
高截留量血液透析( HCO)是近年来血液透析领域重要的研究进展之一,其可有效清除相对分子质量为65000的物质,主要用于治疗骨髓瘤管型肾病、脓毒症、横纹肌溶解征等疾病。骨髓瘤患者由于游离轻链被近曲小管吸收后沉积在上皮细胞胞质内,使肾小管细胞变性,导致急性肾衰竭。大量临床试验证明,HCO可有效清除游离轻链,促进肾功能恢复,改善患者预后。该文就 HCO在多发性骨髓瘤管型肾病中的临床应用进展作一简述。
高截留量血液透析( HCO)是近年來血液透析領域重要的研究進展之一,其可有效清除相對分子質量為65000的物質,主要用于治療骨髓瘤管型腎病、膿毒癥、橫紋肌溶解徵等疾病。骨髓瘤患者由于遊離輕鏈被近麯小管吸收後沉積在上皮細胞胞質內,使腎小管細胞變性,導緻急性腎衰竭。大量臨床試驗證明,HCO可有效清除遊離輕鏈,促進腎功能恢複,改善患者預後。該文就 HCO在多髮性骨髓瘤管型腎病中的臨床應用進展作一簡述。
고절류량혈액투석( HCO)시근년래혈액투석영역중요적연구진전지일,기가유효청제상대분자질량위65000적물질,주요용우치료골수류관형신병、농독증、횡문기용해정등질병。골수류환자유우유리경련피근곡소관흡수후침적재상피세포포질내,사신소관세포변성,도치급성신쇠갈。대량림상시험증명,HCO가유효청제유리경련,촉진신공능회복,개선환자예후。해문취 HCO재다발성골수류관형신병중적림상응용진전작일간술。
High cut-off hemodialysis( HCO) is one of the important studies in field of hemodialysis in recent years,which can effectively remove substances of relative molecular 65 000,mainly used in the treat-ment of myeloma cast nephropathy,sepsis andrhabdomyolysis syndrome.In myeloma patients,free light chain ( FLC) uptake by proximal tubule cells and deposition in the epithelial cell cytopiasm ,lead to renal tubular cell degeneration and acute renal failure.A large number of clinical trials have demonstrated that HCO can effectively remove FLC ,promote the recovery of renal function and improve the prognosis of the patients .Here is to summarize the application of HCO in myeloma cast nephropathy.