中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
Chinese Journal of Woman and Child Health Research
2015年
4期
835-836,872
,共3页
肿瘤坏死因子-α%细胞间粘附分子-1%血管瘤%良性肿瘤
腫瘤壞死因子-α%細胞間粘附分子-1%血管瘤%良性腫瘤
종류배사인자-α%세포간점부분자-1%혈관류%량성종류
tumor necrosis factor alpha (TNF-α)%intercellular adhesion molecule 1(ICAM-1)%hemangioma%innocent tumor
目的 探究肿瘤坏死因子-α( TNF-α)、细胞间粘附分子-1 ( ICAM-1 )在婴幼儿血管瘤中的表达及临床意义.方法 回顾性分析齐河县人民医院自2012年10月至2014年10月收治的婴幼儿血管瘤35例的临床资料. 采用免疫组织化学SP染色法对该组患儿血管瘤及正常皮肤中的TNF-α和ICAM-1表达情况进行检测,并对结果进行分析. 结果 ①血管瘤组与正常皮肤组中TNF-α和ICAM-1表达呈阴性(-)、弱阳性(+)、中度阳性(++)与强阳性(+++)的比例比较差异均有统计学意义(χ2 值为4.22~52.54,均P<0.05);②TNF-α、ICAM-1在血管瘤与正常皮肤的表达经Speaman相关分析可见,血管瘤中TNF-α的表达与ICAM-1的表达情况呈现出正相关性(r=0.55,P<0.05). 结论 TNF-α和ICAM-1在婴幼儿血管瘤中表达均呈阳性,与正常皮肤组织的表达情况有明显差异,推测可能与婴幼儿血管瘤的发病具有相关性.
目的 探究腫瘤壞死因子-α( TNF-α)、細胞間粘附分子-1 ( ICAM-1 )在嬰幼兒血管瘤中的錶達及臨床意義.方法 迴顧性分析齊河縣人民醫院自2012年10月至2014年10月收治的嬰幼兒血管瘤35例的臨床資料. 採用免疫組織化學SP染色法對該組患兒血管瘤及正常皮膚中的TNF-α和ICAM-1錶達情況進行檢測,併對結果進行分析. 結果 ①血管瘤組與正常皮膚組中TNF-α和ICAM-1錶達呈陰性(-)、弱暘性(+)、中度暘性(++)與彊暘性(+++)的比例比較差異均有統計學意義(χ2 值為4.22~52.54,均P<0.05);②TNF-α、ICAM-1在血管瘤與正常皮膚的錶達經Speaman相關分析可見,血管瘤中TNF-α的錶達與ICAM-1的錶達情況呈現齣正相關性(r=0.55,P<0.05). 結論 TNF-α和ICAM-1在嬰幼兒血管瘤中錶達均呈暘性,與正常皮膚組織的錶達情況有明顯差異,推測可能與嬰幼兒血管瘤的髮病具有相關性.
목적 탐구종류배사인자-α( TNF-α)、세포간점부분자-1 ( ICAM-1 )재영유인혈관류중적표체급림상의의.방법 회고성분석제하현인민의원자2012년10월지2014년10월수치적영유인혈관류35례적림상자료. 채용면역조직화학SP염색법대해조환인혈관류급정상피부중적TNF-α화ICAM-1표체정황진행검측,병대결과진행분석. 결과 ①혈관류조여정상피부조중TNF-α화ICAM-1표체정음성(-)、약양성(+)、중도양성(++)여강양성(+++)적비례비교차이균유통계학의의(χ2 치위4.22~52.54,균P<0.05);②TNF-α、ICAM-1재혈관류여정상피부적표체경Speaman상관분석가견,혈관류중TNF-α적표체여ICAM-1적표체정황정현출정상관성(r=0.55,P<0.05). 결론 TNF-α화ICAM-1재영유인혈관류중표체균정양성,여정상피부조직적표체정황유명현차이,추측가능여영유인혈관류적발병구유상관성.
Objective To explore the expressions of tumor necrosis factor alpha ( TNF-α) and intercellular adhesion molecule 1( ICAM-1) and their clinical significance in infantile hemangioma.Methods A retrospective analysis was conducted on the clinical data of 35 cases of infantile hemangioma treated in Qihe County People' s Hospital from October 2012 to October 2014.Immunohistochemical S-P staining method was used to detect the expressions of TNF-αand ICAM-1 in hemangioma group and normal skin group, and the results were analyzed.Results Hemangioma group was significantly different from normal skin group in the proportion of negative( -), weak positive (+), moderate positive(++) and strong positive(+++) expressions of TNF-αand ICAM-1 (χ2 value ranged 4.22 -4.22, all P<0.05).Speaman correlation analysis showed that the expression of TNF-αwas positively correlated with that of ICAM-1 in hemangioma (r=0.55,P<0.05).Conclusion TNF-αand ICAM-1 are positively expressed in hemangioma, which is obviously different from the expressions in normal skin tissues.It is proposed that the positive expressions of TNF-αand ICAM-1 are associated with the pathogenesis of infantile hemangioma.
