中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
Chinese Journal of Woman and Child Health Research
2015年
4期
828-830
,共3页
肺炎支原体肺炎%儿童%肿瘤坏死因子%白介素-13%喘息
肺炎支原體肺炎%兒童%腫瘤壞死因子%白介素-13%喘息
폐염지원체폐염%인동%종류배사인자%백개소-13%천식
mycoplasma pneumonia ( MP)%children%TNF-α%IL-13%wheezing
目的 探究与分析肿瘤坏死因子α(TNF-α)、白介素-13(IL-13)在肺炎支原体肺炎儿童血中的表达及临床意义.方法 选取沂水县人民医院2012年12月至2014年12月收治的120例肺炎支原体肺炎患儿作为研究对象,将其分为肺炎支原体伴喘息组和肺炎支原体肺炎不伴喘息组,每组各60例. 另选择同时期收治的普通肺炎组患儿60例及正常对照组儿童60例,对比各组患儿血清中IL-3及TNF-α的浓度. 结果 肺炎支原体肺炎不伴喘息组与普通肺炎组血清IL-13相比具有显著差异( t=3.25,P<0.05);肺炎支原体肺炎伴喘息组与肺炎支原体肺炎不伴喘息组血清IL-13相比具有显著差异( t=3.38,P<0.05). 肺炎支原体肺炎不伴喘息组与普通肺炎组血清TNF-α相比具有显著差异(t=3.03,P<0.05);肺炎支原体肺炎伴喘息组与肺炎支原体肺炎不伴喘息组血清TNF-α相比具有显著差异(t=3.26,P<0.05). 结论 血清TNF-α、IL-13浓度升高可能与小儿肺炎支原体肺炎喘息样发作有一定的关系,需引起临床医师的重视.
目的 探究與分析腫瘤壞死因子α(TNF-α)、白介素-13(IL-13)在肺炎支原體肺炎兒童血中的錶達及臨床意義.方法 選取沂水縣人民醫院2012年12月至2014年12月收治的120例肺炎支原體肺炎患兒作為研究對象,將其分為肺炎支原體伴喘息組和肺炎支原體肺炎不伴喘息組,每組各60例. 另選擇同時期收治的普通肺炎組患兒60例及正常對照組兒童60例,對比各組患兒血清中IL-3及TNF-α的濃度. 結果 肺炎支原體肺炎不伴喘息組與普通肺炎組血清IL-13相比具有顯著差異( t=3.25,P<0.05);肺炎支原體肺炎伴喘息組與肺炎支原體肺炎不伴喘息組血清IL-13相比具有顯著差異( t=3.38,P<0.05). 肺炎支原體肺炎不伴喘息組與普通肺炎組血清TNF-α相比具有顯著差異(t=3.03,P<0.05);肺炎支原體肺炎伴喘息組與肺炎支原體肺炎不伴喘息組血清TNF-α相比具有顯著差異(t=3.26,P<0.05). 結論 血清TNF-α、IL-13濃度升高可能與小兒肺炎支原體肺炎喘息樣髮作有一定的關繫,需引起臨床醫師的重視.
목적 탐구여분석종류배사인자α(TNF-α)、백개소-13(IL-13)재폐염지원체폐염인동혈중적표체급림상의의.방법 선취기수현인민의원2012년12월지2014년12월수치적120례폐염지원체폐염환인작위연구대상,장기분위폐염지원체반천식조화폐염지원체폐염불반천식조,매조각60례. 령선택동시기수치적보통폐염조환인60례급정상대조조인동60례,대비각조환인혈청중IL-3급TNF-α적농도. 결과 폐염지원체폐염불반천식조여보통폐염조혈청IL-13상비구유현저차이( t=3.25,P<0.05);폐염지원체폐염반천식조여폐염지원체폐염불반천식조혈청IL-13상비구유현저차이( t=3.38,P<0.05). 폐염지원체폐염불반천식조여보통폐염조혈청TNF-α상비구유현저차이(t=3.03,P<0.05);폐염지원체폐염반천식조여폐염지원체폐염불반천식조혈청TNF-α상비구유현저차이(t=3.26,P<0.05). 결론 혈청TNF-α、IL-13농도승고가능여소인폐염지원체폐염천식양발작유일정적관계,수인기림상의사적중시.
Objective To explore and analyze the expressions of TNF-αand IL-13 in children with mycoplasma pneumonia and their clinical significance.Methods Totally 120 cases of MP treated in Yishui County People' s Hospital during the period of December 2012 to December 2014 were selected as research objects, and they were divided into MP with wheezing group and MP without wheezing group with 60 cases in each.Another 60 cases of ordinary pneumonia and 60 normal controls were selected at the same period.The serum IL-13 and TNF-αcontents of each group was compared.Results The IL-13 content of the MP without wheezing group was significantly different from that of ordinary pneumonia group and MP with wheezing group (t value was 3.25 and 3.38, respectively, both P<0.05).The TNF-αcontent of the MP without wheezing group was significantly different from that of ordinary pneumonia group and MP with wheezing group ( t value was 3.03 and 3.26, respectively, both P<0.05).Conclusion Serum contents of TNF-αand IL-13 increasing may be associated with wheezing-like episodes in children with MP, so it needs to attract clinician' s attention.
