CAJ | 학술논문

目的探讨稳定期COPD患者采用低强度持续性踏车式心肺运动试验(CPET)训练的价值.方法选稳定期COPD患者57例,随机分成对照组26例和康复组31例,对照组给予常规治疗及健康宣教,康复组在此基础上进行12周低强度(运动强度为无氧阈时的功率)的踏车式CPET.2组患者在运动前后测定血清IL-8、肿瘤坏死因子α(TNF-α)、丙二醛(MDA)、超氧化物歧化酶(SOD)、6分钟步行距离、COPD评估测试量表(CAT).结果经过12周的运动训练,康复组患者血清IL-8、TNF-α、MDA水平较治疗前均有降低,SOD水平较前增加,且运动后均明显优于对照组,差异有统计学意义(P＜0.05);2组患者6分钟步行距离明显增加,CAT评分显著降低,上述指标康复组均明显优于对照组,差异有统计学意义(P ＜0.05).结论低强度持续CPET能够改善COPD炎症反应、氧化应激及生活质量,适用于稳定期COPD患者康复治疗.
목적 탐토은정기COPD환자채용저강도지속성답차식심폐운동시험(CPET)훈련적개치.방법 선은정기COPD환자57례,수궤분성대조조26례화강복조31례,대조조급여상규치료급건강선교,강복조재차기출상진행12주저강도(운동강도위무양역시적공솔)적답차식CPET.2조환자재운동전후측정혈청IL-8、종류배사인자α(TNF-α)、병이철(MDA)、초양화물기화매(SOD)、6분종보행거리、COPD평고측시량표(CAT).결과 경과12주적운동훈련,강복조환자혈청IL-8、TNF-α、MDA수평교치료전균유강저,SOD수평교전증가,차운동후균명현우우대조조,차이유통계학의의(P＜0.05);2조환자6분종보행거리명현증가,CAT평분현저강저,상술지표강복조균명현우우대조조,차이유통계학의의(P ＜0.05).결론 저강도지속CPET능구개선COPD염증반응、양화응격급생활질량,괄용우은정기COPD환자강복치료.
Objective To explore the clinical value of persistent low-intensity cycle ergometer training in patients with stable chronic obstructive pulmonary disease (COPD).Methods Fifty-seven patients with stable COPD were randomly divided into a control (26 cases),a treatment (31 cases).All patients received conventional medical therapy and health education,meanwhile patients of treatment group added low-intensity (exercise intensity level measured by anaerobic threshold) cycle ergometer training,which was for a period of 12 weeks,3 5 times per week,each 30 minutes.Serum IL-8,TNF-α,MDA,SOD levels and 6-minute walking distance,CAT were detected both before and after the training.Results At 12 weeks,the serum IL-8,TNF-α,MDA levels were decreased and the serum SOD level was improved in the treatment group,which was better than the control group,the difference was of statistical significance (P ＜ 0.05).6-minute walking distance was significantly increased,CAT scores were significantly reduced in the two groups,and these indictors in the treatment group were better than the control group,the difference was of statistical significance (P ＜ 0.05).Conclusions Persistent low-intensity CPET improving the inflammatory response,oxidative stress and quality of life,which is suitable for patients with stable COPD.