CAJ | 학술논문

微RNA（ miRNA）是一类长约22个核苷酸的内源性非蛋白质编码的小分子 RNA，它通过对目标mRNA的剪切和翻译抑制，发挥对基因表达的转录后调控作用。 miRNA具有多靶点的特性，至少参与约1／3人类蛋白质的表达调控，并且参与调控细胞分化、凋亡，肿瘤形成、免疫反应等多种生物学行为。近些年研究表明，miRNA对于调控非酒精性脂肪性肝病的基因表达、调节脂质形成和储存至关重要。
미RNA（ miRNA）시일류장약22개핵감산적내원성비단백질편마적소분자 RNA，타통과대목표mRNA적전절화번역억제，발휘대기인표체적전록후조공작용。 miRNA구유다파점적특성，지소삼여약1／3인류단백질적표체조공，병차삼여조공세포분화、조망，종류형성、면역반응등다충생물학행위。근사년연구표명，miRNA대우조공비주정성지방성간병적기인표체、조절지질형성화저존지관중요。
MicroRNA( miRNA) is a class of 22 nucleotides endogenous non-protein-coding small mole-cule RNA,which regulates gene expression after transcription through splicing and translation of the target mRNA inhibition.miRNA has multiple targets,and is involved in the expression regulation of at least about 1/3 human protein,and participates in biological behaviors including the regulation of cell differentiation , apoptosis,tumor formation,and immune response.In recent years,research shows that miRNA is essential to the regulation of gene expression of nonalcoholic fatty liver disease, lipid formation and storage.