实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
2015年
7期
61-63
,共3页
心肌梗死%氯吡格雷%西洛他唑%血管成形术, 气囊, 冠状动脉%血小板聚集
心肌梗死%氯吡格雷%西洛他唑%血管成形術, 氣囊, 冠狀動脈%血小闆聚集
심기경사%록필격뢰%서락타서%혈관성형술, 기낭, 관상동맥%혈소판취집
Myocardial infarction%Clopidogrel%Cilostazol%Angioplasty,balloon,coronary%Platelet aggregation
目的：探讨氯吡格雷联合西洛他唑对行经皮冠状动脉介入治疗（ PCI）的急性心肌梗死（ AMI）患者术后出血事件及血小板聚集率的影响。方法选取2011年6月—2013年6月在山东省乐陵市人民医院成功行PCI的AMI患者128例，按照随机数字表法分为观察组和对照组，各64例。对照组患者PCI术后给予阿司匹林联合氯吡格雷治疗，观察组患者PCI术后给予西洛他唑联合氯吡格雷治疗，两组患者均持续用药12周。比较两组患者用药前及用药后1周、6周、12周血小板聚集率和随访期间出血事件及不良心脏事件发生情况。结果两组患者用药前血小板聚集率比较，差异无统计学意义（P＞0.05）；观察组患者用药后1周、6周、12周血小板聚集率低于对照组（P＜0.05）。随访期间观察组患者再次血运重建、再发心绞痛、出血事件发生率低于对照组（ P＜0.05）；而两组患者心肌梗死、脑卒中发生率及全因死亡率比较，差异无统计学意义（ P＞0.05）。结论氯吡格雷联合西洛他唑治疗能有效降低AMI患者PCI术后血小板聚集率及出血事件发生率，且安全性较高。
目的：探討氯吡格雷聯閤西洛他唑對行經皮冠狀動脈介入治療（ PCI）的急性心肌梗死（ AMI）患者術後齣血事件及血小闆聚集率的影響。方法選取2011年6月—2013年6月在山東省樂陵市人民醫院成功行PCI的AMI患者128例，按照隨機數字錶法分為觀察組和對照組，各64例。對照組患者PCI術後給予阿司匹林聯閤氯吡格雷治療，觀察組患者PCI術後給予西洛他唑聯閤氯吡格雷治療，兩組患者均持續用藥12週。比較兩組患者用藥前及用藥後1週、6週、12週血小闆聚集率和隨訪期間齣血事件及不良心髒事件髮生情況。結果兩組患者用藥前血小闆聚集率比較，差異無統計學意義（P＞0.05）；觀察組患者用藥後1週、6週、12週血小闆聚集率低于對照組（P＜0.05）。隨訪期間觀察組患者再次血運重建、再髮心絞痛、齣血事件髮生率低于對照組（ P＜0.05）；而兩組患者心肌梗死、腦卒中髮生率及全因死亡率比較，差異無統計學意義（ P＞0.05）。結論氯吡格雷聯閤西洛他唑治療能有效降低AMI患者PCI術後血小闆聚集率及齣血事件髮生率，且安全性較高。
목적：탐토록필격뢰연합서락타서대행경피관상동맥개입치료（ PCI）적급성심기경사（ AMI）환자술후출혈사건급혈소판취집솔적영향。방법선취2011년6월—2013년6월재산동성악릉시인민의원성공행PCI적AMI환자128례，안조수궤수자표법분위관찰조화대조조，각64례。대조조환자PCI술후급여아사필림연합록필격뢰치료，관찰조환자PCI술후급여서락타서연합록필격뢰치료，량조환자균지속용약12주。비교량조환자용약전급용약후1주、6주、12주혈소판취집솔화수방기간출혈사건급불양심장사건발생정황。결과량조환자용약전혈소판취집솔비교，차이무통계학의의（P＞0.05）；관찰조환자용약후1주、6주、12주혈소판취집솔저우대조조（P＜0.05）。수방기간관찰조환자재차혈운중건、재발심교통、출혈사건발생솔저우대조조（ P＜0.05）；이량조환자심기경사、뇌졸중발생솔급전인사망솔비교，차이무통계학의의（ P＞0.05）。결론록필격뢰연합서락타서치료능유효강저AMI환자PCI술후혈소판취집솔급출혈사건발생솔，차안전성교고。
Objective To investigate the impact of clopidogrel combined with cilostazol on postoperative bleeding events and platelet aggregation rate in acute myocardial infarction patients successfully treated by PCI.Methods A total of 128 acute myocardial infarction patients successfully treated by PCI were selected in People′s Hospital of Laoling from June 2011 to June 2013, and they were divided into control group and observation group according to random number table, each of 64 cases.Patients of control group were given aspirin combined with clopidogrel after PCI, while patients of observation group were given clopidogrel combined with cilostazol after PCI, both groups treated for 12 weeks.Platelet aggregation rate before medication and after 1 week, 6 weeks, 12 weeks of medication, incidence of bleeding events and adverse cardiac events during fellow-up were compared between the two groups.Results No statistically significant differences of platelet aggregation rate was found between the two groups before medication ( P >0.05 ) , while platelet aggregation rate of observation group was statistically significantly lower than that of control group after 1 week, 6 weeks, 12 weeks of medication, respectively (P<0.05).The incidence of repeat revascularization, recurrent angina pectoris, bleeding events of observation group was statistically significantly lower than that of control group during fellow-up, respectively ( P <0.05 ); while no statistically significant differences of incidence of myocardial infarction, stroke or all -cause mortality was found between the two groups during fellow-up ( P>0.05).Conclusion Clopidogrel combined with cilostazol can effectively reduce the incidence of postoperative bleeding events and platelet aggregation rate in acute myocardial infarction patients successfully treated by PCI, is with high safety.
