CAJ | 학술논문

目的：分析隐源性肝硬化（CC）患者发生肝细胞肝癌（HCC）的危险因素。方法回顾性收集新疆医科大学第一附属医院2009年7月—2014年7月符合纳入与排除标准的CC患者241例。按照诊断结果将患者分为单纯CC组（222例）和CC合并HCC组（19例）。收集并比较患者性别、年龄、民族、体质量、是否合并高血压、是否合并糖尿病、恶性肿瘤家族史、药物过敏史、Child-Pugh评分、血红蛋白、平均红细胞体积、球蛋白、三酰甘油、总胆固醇、尿酸、肌酐、尿蛋白等指标。结果单因素条件Logistic回归分析结果显示，年龄、是否合并高血压、尿蛋白是CC患者发生HCC的影响因素（ P<0.05）。多因素非条件Logistic逐步回归分析结果显示，以α=0.05为显著水准，进入回归模型的变量有年龄、合并高血压（P<0.05）。结论高血压和年龄高是CC患者发生HCC的危险因素，应对CC患者血压升高及年龄予以重视，正确评估，以降低其发生HCC的风险。
목적：분석은원성간경화（CC）환자발생간세포간암（HCC）적위험인소。방법회고성수집신강의과대학제일부속의원2009년7월—2014년7월부합납입여배제표준적CC환자241례。안조진단결과장환자분위단순CC조（222례）화CC합병HCC조（19례）。수집병비교환자성별、년령、민족、체질량、시부합병고혈압、시부합병당뇨병、악성종류가족사、약물과민사、Child-Pugh평분、혈홍단백、평균홍세포체적、구단백、삼선감유、총담고순、뇨산、기항、뇨단백등지표。결과단인소조건Logistic회귀분석결과현시，년령、시부합병고혈압、뇨단백시CC환자발생HCC적영향인소（ P<0.05）。다인소비조건Logistic축보회귀분석결과현시，이α=0.05위현저수준，진입회귀모형적변량유년령、합병고혈압（P<0.05）。결론고혈압화년령고시CC환자발생HCC적위험인소，응대CC환자혈압승고급년령여이중시，정학평고，이강저기발생HCC적풍험。
Objective To investigate the risk factors for the occurrence of hepatocellular carcinoma( HCC)in patients with cryptogenic cirrhosis( CC) . Methods 241 CC patients who accorded with the inclusion and exclusion criteria from the First Teaching Hospital of Xinjiang Medical University between July 2009 and July 2014 were enrolled in the study. According to the results of diagnoses,the subjects were divided into two groups:CC group(n =222)and CC +HCC group(n =19). Comparison was made between the two groups in gender, age, ethnic group, body mass, whether complicated with hypertension,whether complicated with diabetes mellitus,family history of malignant tumor,drug allergy history,Child-Pugh score, hemoglobin, mean corpuscular volume, globulin, triacylglycerol, total cholesterol, uric acid, creatinine and urine protein. Results Univariate conditional Logistic regression analysis showed that age,urine protein and whether complicated with hypertension were influencing factors for HCC in CC patients( P <0. 05 ) . Multivariate non - conditional Logistic stepwise regression analysis showed that,with α=0. 05 as the outstanding standard,the variables that entered regression model included age and being complicated with hypertension(P<0. 05). Conclusion Age and hypertention are risk factors for HCC in patients with CC. The elevation of blood pressure and age should be paid special attention and evaluated correctly,in order to reduce the risk of HCC in CC patients.