CAJ | 학술논문

端粒是真核细胞维持自身染色体稳定的重要成分，其 DNA 序列位于染色体的末端，端粒的长度会随着染色体的不完全复制和细胞分裂而逐渐缩短。端粒酶相关基因的突变会造成端粒酶活性的降低以及端粒长度缩短，过短的端粒无法保护基因组维持正常的稳定性，最终造成细胞的老化、凋亡或恶变。人端粒酶反转录酶（ hTERT）基因的表达水平与端粒酶的活性一致，其表达被认为是端粒酶活性的关键步骤。该文就hTERT与肿瘤的关系予以综述。
단립시진핵세포유지자신염색체은정적중요성분，기 DNA 서렬위우염색체적말단，단립적장도회수착염색체적불완전복제화세포분렬이축점축단。단립매상관기인적돌변회조성단립매활성적강저이급단립장도축단，과단적단립무법보호기인조유지정상적은정성，최종조성세포적노화、조망혹악변。인단립매반전록매（ hTERT）기인적표체수평여단립매적활성일치，기표체피인위시단립매활성적관건보취。해문취hTERT여종류적관계여이종술。
Telomerase is an essential ingredient of the eukaryotic cells to maintain its stability ,with the DNA sequence locating at the end of the chromosome,and the telomere length is gradually shortened with the incomplete chromosome replication and cell division .Telomerase gene mutations can lead to low telomerase activity and shortened telomere length,too short telomeres are unable to protect the stability of the genome, resulting in cell aging, apoptosis or malignant transformation.Human telomerase reverse transcriptase (hTERT) is one important component of telomerase,and telomerase activity is consistent with the hTERT gene expression level,so its expression is considered to be the key step in the telomerase activity.Here is to make a review of the correlation between hTERT and tumors.