实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
2015年
7期
11-14
,共4页
脑缺血%早期神经功能恶化%危险因素
腦缺血%早期神經功能噁化%危險因素
뇌결혈%조기신경공능악화%위험인소
Brain ischemia%Early neurological deterioration%Risk factors
目的:探讨急性缺血性卒中患者早期神经功能恶化的危险因素。方法选取2012年7月—2014年6月安阳市人民医院收治的急性缺血性卒中患者260例,根据患者是否发生早期神经功能恶化分为发生早期神经功能恶化77例(进展组)和未发生早期神经功能恶化183例(非进展组)。回顾性分析患者的临床资料,记录患者年龄、性别、合并疾病(高血压、高脂血症、糖尿病、缺血性心脏病)、既往卒中或短暂性脑缺血发作( TIA)史、吸烟情况、饮酒情况、发热情况、入院时收缩压、入院时舒张压、血脂指标、空腹血糖、纤维蛋白原、基线美国国立卫生研究院卒中量表( NIHSS)评分、梗死体积、 TOAST病因学分型及治疗用药情况,采用多因素Logistic回归分析对急性缺血性卒中患者早期神经功能恶化的危险因素进行分析。结果两组患者年龄、性别、高血压发生率、吸烟率、饮酒率、入院时舒张压、血脂指标、 TOAST病因学分型及治疗用药比较,差异均无统计学意义( P>0.05);进展组患者高脂血症、糖尿病、缺血性心脏病、发热发生率和既往卒中或TIA史阳性率、基线NIHSS评分、空腹血糖及纤维蛋白原水平高于非进展组,梗死体积大于非进展组,入院时收缩压低于非进展组( P<0.05)。多因素Logistic回归分析结果显示,空腹血糖偏高〔OR=1.31,95%CI (1.02,1.74)〕、既往有卒中或TIA史〔OR=1.14,95%CI (1.01,1.35)〕、基线NIHSS评分偏高〔OR=1.08,95%CI (1.04,1.13)〕、发热〔OR=1.01,95%CI (1.00,1.47)〕、纤维蛋白原偏高〔OR=1.04,95%CI (1.00,1.23)〕、入院时收缩压偏低〔OR=1.03,95%CI (1.01,1.13)〕是急性缺血性卒中患者早期神经功能恶化的独立危险因素( P<0.05)。结论空腹血糖偏高、既往卒中或TIA史、发热、基线NIHSS评分偏高、纤维蛋白原偏高、入院时收缩压偏低是急性缺血性卒中患者早期神经功能恶化的危险因素,应加强治疗和护理,以降低早期神经功能恶化发生率。
目的:探討急性缺血性卒中患者早期神經功能噁化的危險因素。方法選取2012年7月—2014年6月安暘市人民醫院收治的急性缺血性卒中患者260例,根據患者是否髮生早期神經功能噁化分為髮生早期神經功能噁化77例(進展組)和未髮生早期神經功能噁化183例(非進展組)。迴顧性分析患者的臨床資料,記錄患者年齡、性彆、閤併疾病(高血壓、高脂血癥、糖尿病、缺血性心髒病)、既往卒中或短暫性腦缺血髮作( TIA)史、吸煙情況、飲酒情況、髮熱情況、入院時收縮壓、入院時舒張壓、血脂指標、空腹血糖、纖維蛋白原、基線美國國立衛生研究院卒中量錶( NIHSS)評分、梗死體積、 TOAST病因學分型及治療用藥情況,採用多因素Logistic迴歸分析對急性缺血性卒中患者早期神經功能噁化的危險因素進行分析。結果兩組患者年齡、性彆、高血壓髮生率、吸煙率、飲酒率、入院時舒張壓、血脂指標、 TOAST病因學分型及治療用藥比較,差異均無統計學意義( P>0.05);進展組患者高脂血癥、糖尿病、缺血性心髒病、髮熱髮生率和既往卒中或TIA史暘性率、基線NIHSS評分、空腹血糖及纖維蛋白原水平高于非進展組,梗死體積大于非進展組,入院時收縮壓低于非進展組( P<0.05)。多因素Logistic迴歸分析結果顯示,空腹血糖偏高〔OR=1.31,95%CI (1.02,1.74)〕、既往有卒中或TIA史〔OR=1.14,95%CI (1.01,1.35)〕、基線NIHSS評分偏高〔OR=1.08,95%CI (1.04,1.13)〕、髮熱〔OR=1.01,95%CI (1.00,1.47)〕、纖維蛋白原偏高〔OR=1.04,95%CI (1.00,1.23)〕、入院時收縮壓偏低〔OR=1.03,95%CI (1.01,1.13)〕是急性缺血性卒中患者早期神經功能噁化的獨立危險因素( P<0.05)。結論空腹血糖偏高、既往卒中或TIA史、髮熱、基線NIHSS評分偏高、纖維蛋白原偏高、入院時收縮壓偏低是急性缺血性卒中患者早期神經功能噁化的危險因素,應加彊治療和護理,以降低早期神經功能噁化髮生率。
목적:탐토급성결혈성졸중환자조기신경공능악화적위험인소。방법선취2012년7월—2014년6월안양시인민의원수치적급성결혈성졸중환자260례,근거환자시부발생조기신경공능악화분위발생조기신경공능악화77례(진전조)화미발생조기신경공능악화183례(비진전조)。회고성분석환자적림상자료,기록환자년령、성별、합병질병(고혈압、고지혈증、당뇨병、결혈성심장병)、기왕졸중혹단잠성뇌결혈발작( TIA)사、흡연정황、음주정황、발열정황、입원시수축압、입원시서장압、혈지지표、공복혈당、섬유단백원、기선미국국립위생연구원졸중량표( NIHSS)평분、경사체적、 TOAST병인학분형급치료용약정황,채용다인소Logistic회귀분석대급성결혈성졸중환자조기신경공능악화적위험인소진행분석。결과량조환자년령、성별、고혈압발생솔、흡연솔、음주솔、입원시서장압、혈지지표、 TOAST병인학분형급치료용약비교,차이균무통계학의의( P>0.05);진전조환자고지혈증、당뇨병、결혈성심장병、발열발생솔화기왕졸중혹TIA사양성솔、기선NIHSS평분、공복혈당급섬유단백원수평고우비진전조,경사체적대우비진전조,입원시수축압저우비진전조( P<0.05)。다인소Logistic회귀분석결과현시,공복혈당편고〔OR=1.31,95%CI (1.02,1.74)〕、기왕유졸중혹TIA사〔OR=1.14,95%CI (1.01,1.35)〕、기선NIHSS평분편고〔OR=1.08,95%CI (1.04,1.13)〕、발열〔OR=1.01,95%CI (1.00,1.47)〕、섬유단백원편고〔OR=1.04,95%CI (1.00,1.23)〕、입원시수축압편저〔OR=1.03,95%CI (1.01,1.13)〕시급성결혈성졸중환자조기신경공능악화적독립위험인소( P<0.05)。결론공복혈당편고、기왕졸중혹TIA사、발열、기선NIHSS평분편고、섬유단백원편고、입원시수축압편저시급성결혈성졸중환자조기신경공능악화적위험인소,응가강치료화호리,이강저조기신경공능악화발생솔。
Objective To investigate the risk factors of early neurological deterioration in patients with acute ischemic stroke.Methods A total of 260 patients with acute ischemic stroke were selected in the People′s Hospital of Anyang from July 2012 to June 2014, and they were divided into A ( with early neurological deterioration, n=77 ) and B group ( without early neurological deterioration, n =183 ) according to the incidence of early neurological deterioration.Clinical data was retrospectively analyzed, including age, gender, coexistent diseases ( including hypertension, hyperlipidaemia, diabetes mellitus, ischemic heart disease ) , stroke or TIA history, smoking rate, drinking rate, incidence of fever, systolic blood pressure at admission, diastolic blood pressure at admission, blood lipid parameters, FPG, FIB, baseline NIHSS score, infarction volume, TOAST etiological types and therapeutic medications, multivariate Logistic regression analysis was used to analyze the risk factors of early neurological deterioration in patients with acute ischemic stroke. Results No statistically significant differences of age, gender, incidence of hypertension, smoking rate, drinking rate, diastolic blood pressure at admission, blood lipid parameters, TOAST etiological types or therapeutic medications was found between the two groups ( P>0.05); the incidence of hyperlipidaemia, diabetes mellitus, ischemic heart disease and fever, positive rate of stroke or TIA history, baseline NIHSS score, FPG and FIB of A group were statistically significantly higher than those of B group, infarction volume of A group was statistically significantly larger than that of B group, while systolic blood pressure at admission of A group was statistically significantly lower than that of B group ( P <0.05).Multivariate Logistic regression analysis showed that, increased FPG 〔OR=1.31, 95%CI (1.02, 1.74)〕, positive stroke or TIA history 〔OR=1.14, 95%CI (1.01, 1.35)〕, increased baseline NIHSS score 〔OR =1.08, 95%CI ( 1.04, 1.13 )〕, fever 〔OR =1.01, 95%CI ( 1.00, 1.47 )〕, increased FIB 〔OR=1.04, 95%CI (1.00, 1.23)〕, decreased systolic blood pressure at admission 〔OR=1.03, 95%CI (1.01, 1.13)〕 were risk factors of early neurological deterioration in patients with acute ischemic stroke ( P <0.05). Conclusion Increased FPG, positivestroke or TIA history, increased baseline NIHSS score, fever, increased FIB, decreased systolic blood pressure at admission are risk factors of early neurological deterioration in patients with acute ischemic stroke, patients with above factors should be pay more attentions to, in order to reduce the incidence of early neurological deterioration.