CAJ | 학술논문

肿瘤单一药物治疗的效果往往不佳,且易产生耐药性,因此,肿瘤的多药协同治疗具有明显优势,并逐渐引起重视。本工作基于具有良好生物相容性和生物可降解性的聚乙二醇-嵌段-聚乳酸( PEG-b-PLA)两嵌段聚合物,物理包埋两种化疗药物,阿霉素( Doxorubicin, DOX)和喜树碱( Camptothecin, CPT),实现两种化疗药物的共传输、药物释放与协同给药,表现出良好的抗肿瘤活性。
종류단일약물치료적효과왕왕불가,차역산생내약성,인차,종류적다약협동치료구유명현우세,병축점인기중시。본공작기우구유량호생물상용성화생물가강해성적취을이순-감단-취유산( PEG-b-PLA)량감단취합물,물리포매량충화료약물,아매소( Doxorubicin, DOX)화희수감( Camptothecin, CPT),실현량충화료약물적공전수、약물석방여협동급약,표현출량호적항종류활성。
The therapeutic efficiency of tumors upon treating with single drug is usually unsatisfactory, which would probably result in drug resistance. Hence, the multi-drug synergetic therapy against tumors has exhibited some advanta-ges and attracted attention gradually. In the current work, biocompatible and biodegradable poly( ethylene glycol)-b-poly (lactic acid), (PEG-b-PLA), was employed to encapsulate two types of anticancer drug, doxorubicin (DOX) and camptothecin( CPT) . It was demonstrated that dual drug delivery, release, and synergetic drug treatment was realized in the nanocarrier, exhibiting good anticancer activity.