国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
International Journal of Traditional Chinese Medicine
2015年
9期
796-799
,共4页
朱磊%胡丹%张晓文%钮明杨%尹红
硃磊%鬍丹%張曉文%鈕明楊%尹紅
주뢰%호단%장효문%뉴명양%윤홍
手足口病%脑损伤%丹参注射液%中西医结合疗法
手足口病%腦損傷%丹參註射液%中西醫結閤療法
수족구병%뇌손상%단삼주사액%중서의결합요법
Hand%foot and mouth disease%Brain injuries%Dan Shen Zhu She Ye%Integrated Chinese traditional and Western medicine therapy
目的 观察丹参注射液联合西医常规疗法治疗重症手足口病的临床疗效.方法 将符合纳入标准的140例重症手足口病患儿按随机数字表法分为2组各70例.对照组采用西医常规治疗,观察组在对照组基础上加用丹参注射液,均治疗7 d.采用酶联免疫吸附法(enzyme-linked immunosorbent assay, ELISA)检测患儿血浆S-100β蛋白、血清神经元特异性烯醇化酶(neuron-specific enolase, NSE)、肿瘤坏死因子-α(tumor necrosis factor-α, TFN-α)、白细胞介素-6(interleukin-6, IL-6)水平,比较2组患儿发热消退时间、口腔疱疹和手足皮疹愈合时间,评价临床疗效.结果 观察组与对照组总有效率分别为92.9%(65/70)、80.0%(56/70),2 组比较差异有统计学意义(χ2=3.897,P=0.048).治疗后,观察组血清 NSE[(9.42± 2.56)μg/L比(11.71±3.21)μg/L,t=2.159]、S-100β[(177.34± 87.28)ng/L比(286.14±159.69)ng/L,t=2.315]水平,以及TNF-α[(15.98±4.35)ng/L比(23.17±4.80)ng/L,t=4.297]、IL-6[(41.72±6.64)ng/L比(52.05±9.33)ng/L,t=3.492]水平均低于对照组(P<0.05 或 P<0.01).观察组退热时间[(3.55±1.02)d 比(4.46±0.97)d,t=5.409]、皮疹消退时间[(4.55±1.09)d比(5.88±1.44)d,t=6.161]、住院时间[(7.14±1.04)d比(8.68±1.06)d,t=8.677]均较对照组缩短(P<0.01).结论 在常规治疗基础上加用丹参注射液可有效减轻重症手足口病患儿全身炎性反应,改善脑损伤,提高临床疗效.
目的 觀察丹參註射液聯閤西醫常規療法治療重癥手足口病的臨床療效.方法 將符閤納入標準的140例重癥手足口病患兒按隨機數字錶法分為2組各70例.對照組採用西醫常規治療,觀察組在對照組基礎上加用丹參註射液,均治療7 d.採用酶聯免疫吸附法(enzyme-linked immunosorbent assay, ELISA)檢測患兒血漿S-100β蛋白、血清神經元特異性烯醇化酶(neuron-specific enolase, NSE)、腫瘤壞死因子-α(tumor necrosis factor-α, TFN-α)、白細胞介素-6(interleukin-6, IL-6)水平,比較2組患兒髮熱消退時間、口腔皰疹和手足皮疹愈閤時間,評價臨床療效.結果 觀察組與對照組總有效率分彆為92.9%(65/70)、80.0%(56/70),2 組比較差異有統計學意義(χ2=3.897,P=0.048).治療後,觀察組血清 NSE[(9.42± 2.56)μg/L比(11.71±3.21)μg/L,t=2.159]、S-100β[(177.34± 87.28)ng/L比(286.14±159.69)ng/L,t=2.315]水平,以及TNF-α[(15.98±4.35)ng/L比(23.17±4.80)ng/L,t=4.297]、IL-6[(41.72±6.64)ng/L比(52.05±9.33)ng/L,t=3.492]水平均低于對照組(P<0.05 或 P<0.01).觀察組退熱時間[(3.55±1.02)d 比(4.46±0.97)d,t=5.409]、皮疹消退時間[(4.55±1.09)d比(5.88±1.44)d,t=6.161]、住院時間[(7.14±1.04)d比(8.68±1.06)d,t=8.677]均較對照組縮短(P<0.01).結論 在常規治療基礎上加用丹參註射液可有效減輕重癥手足口病患兒全身炎性反應,改善腦損傷,提高臨床療效.
목적 관찰단삼주사액연합서의상규요법치료중증수족구병적림상료효.방법 장부합납입표준적140례중증수족구병환인안수궤수자표법분위2조각70례.대조조채용서의상규치료,관찰조재대조조기출상가용단삼주사액,균치료7 d.채용매련면역흡부법(enzyme-linked immunosorbent assay, ELISA)검측환인혈장S-100β단백、혈청신경원특이성희순화매(neuron-specific enolase, NSE)、종류배사인자-α(tumor necrosis factor-α, TFN-α)、백세포개소-6(interleukin-6, IL-6)수평,비교2조환인발열소퇴시간、구강포진화수족피진유합시간,평개림상료효.결과 관찰조여대조조총유효솔분별위92.9%(65/70)、80.0%(56/70),2 조비교차이유통계학의의(χ2=3.897,P=0.048).치료후,관찰조혈청 NSE[(9.42± 2.56)μg/L비(11.71±3.21)μg/L,t=2.159]、S-100β[(177.34± 87.28)ng/L비(286.14±159.69)ng/L,t=2.315]수평,이급TNF-α[(15.98±4.35)ng/L비(23.17±4.80)ng/L,t=4.297]、IL-6[(41.72±6.64)ng/L비(52.05±9.33)ng/L,t=3.492]수평균저우대조조(P<0.05 혹 P<0.01).관찰조퇴열시간[(3.55±1.02)d 비(4.46±0.97)d,t=5.409]、피진소퇴시간[(4.55±1.09)d비(5.88±1.44)d,t=6.161]、주원시간[(7.14±1.04)d비(8.68±1.06)d,t=8.677]균교대조조축단(P<0.01).결론 재상규치료기출상가용단삼주사액가유효감경중증수족구병환인전신염성반응,개선뇌손상,제고림상료효.
Objective To observe the effect of Danshen in the treatment of severe hand-foot-and-mouth disease and investigate its mechanism.Methods One hundred and forty cases of children with severe hand foot and mouth diseases who hospitalized the intensive care unit were enrolled in the study from February 2012 to July 2014.The children were randomly divided into a control group and an observation group,with 70 cases in each group.The control group was given antiviral to reduce the intracranial pressure and intravenous immunoglobulin and the observation group was given Danshen in addition to the control group.The levels of neuron specific enolase (NSE)、S-100βprotein、TNF-α and IL-6 were detected at admission and checked again seven days after treatment.The changes of the above indicators and the clinical curative effect were compared before and after therapy.Results The total effective rate of the control group and the observation group was 80.0% and 92.9% respectively,showing statistical significance(P<0.05). After treatment, observation group of serum NSE (9.42 ± 2.56μg/Lvs. 11.71 ± 3.21μg/L,t=2.159), S-100β (177.34 ± 87.28 ng/Lvs. 286.14 ± 159.69 ng/L, t=2.315), TNF-α (15.98 ± 4.35 ng/Lvs. 23.17 ± 4.80 ng/L, t=4.297), IL-6 (41.72 ± 6.64 ng/Lvs. 52.05 ± 9.33 ng/L,t=3.492) , the level of were lower than those in the control group (P<0.05 orP<0.01). In the observation group, serum. The fever clearance time、the disappearance time of rash and the hospitalization time in the observation group (3.55 ± 1.02 d vs.4.55 ± 1.09 d, 7.14 ± 1.04 d) were shorter than those in the control group (4.46 ± 0.97 d vs.5.88 ± 1.44 d, 8.68 ± 1.06 d;t=5.409, 6.161, 8.677 respectively, P<0.01).Conclusions On the basis of conventional therapy,Danshen can effectively alleviate the systemic inflammatory response in children with severe hand foot and mouth diseases, reduce brain damage and improve the clinical efficacy.
