国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
International Journal of Traditional Chinese Medicine
2015年
9期
800-802
,共3页
冠状动脉疾病%心脏病%老年人%血液流变学%炙甘草汤
冠狀動脈疾病%心髒病%老年人%血液流變學%炙甘草湯
관상동맥질병%심장병%노년인%혈액류변학%자감초탕
Coronary disease%Heart diseases%Aged%Hemorheology%Zhi Gan Cao Tang
目的 评价炙甘草汤加减治疗老年冠心病的临床疗效.方法 将符合纳入标准的 174 例60岁以上的冠心病患者按随机数字表法分为2组各87例.对照组采用西医常规疗法治疗,观察组采用炙甘草汤加减治疗.观察2组患者的临床疗效及治疗前后血液流变学指标的变化.结果 治疗后,观察组、对照组心绞痛疗效总有效率分别为89.7%(78/87)、67.8%(59/87),2组比较差异有统计学意义(χ2=11.122, P=0.001);心电图疗效总有效率分别为80.5%(70/87)、62.1%(45/87),2组比较差异有统计学意义(χ2=14.771,P值<0.01).观察组血浆黏度[(1.48±0.31)mPa·s比(1.61±0.29)mPa·s,t=2.856]、全血黏度低切[(6.01±0.85)mPa·s 比(6.42±1.34)mPa·s , t=2.410]、全血黏度高切[(4.03±0.45)mPa·s 比(4.47±0.36)mPa·s,t=7.122])、红细胞压积[(39.75±4.09)%比(43.98±4.17)%,t=6.755]、纤维蛋白原[(3.21±0.38)g/L比(4.05±0.42)g/L,t=13.833]均明显低于对照组(P<0.01或P<0.05).结论 炙甘草汤加减可改善老年冠心病患者的血液流变学,且不良反应小.
目的 評價炙甘草湯加減治療老年冠心病的臨床療效.方法 將符閤納入標準的 174 例60歲以上的冠心病患者按隨機數字錶法分為2組各87例.對照組採用西醫常規療法治療,觀察組採用炙甘草湯加減治療.觀察2組患者的臨床療效及治療前後血液流變學指標的變化.結果 治療後,觀察組、對照組心絞痛療效總有效率分彆為89.7%(78/87)、67.8%(59/87),2組比較差異有統計學意義(χ2=11.122, P=0.001);心電圖療效總有效率分彆為80.5%(70/87)、62.1%(45/87),2組比較差異有統計學意義(χ2=14.771,P值<0.01).觀察組血漿黏度[(1.48±0.31)mPa·s比(1.61±0.29)mPa·s,t=2.856]、全血黏度低切[(6.01±0.85)mPa·s 比(6.42±1.34)mPa·s , t=2.410]、全血黏度高切[(4.03±0.45)mPa·s 比(4.47±0.36)mPa·s,t=7.122])、紅細胞壓積[(39.75±4.09)%比(43.98±4.17)%,t=6.755]、纖維蛋白原[(3.21±0.38)g/L比(4.05±0.42)g/L,t=13.833]均明顯低于對照組(P<0.01或P<0.05).結論 炙甘草湯加減可改善老年冠心病患者的血液流變學,且不良反應小.
목적 평개자감초탕가감치료노년관심병적림상료효.방법 장부합납입표준적 174 례60세이상적관심병환자안수궤수자표법분위2조각87례.대조조채용서의상규요법치료,관찰조채용자감초탕가감치료.관찰2조환자적림상료효급치료전후혈액류변학지표적변화.결과 치료후,관찰조、대조조심교통료효총유효솔분별위89.7%(78/87)、67.8%(59/87),2조비교차이유통계학의의(χ2=11.122, P=0.001);심전도료효총유효솔분별위80.5%(70/87)、62.1%(45/87),2조비교차이유통계학의의(χ2=14.771,P치<0.01).관찰조혈장점도[(1.48±0.31)mPa·s비(1.61±0.29)mPa·s,t=2.856]、전혈점도저절[(6.01±0.85)mPa·s 비(6.42±1.34)mPa·s , t=2.410]、전혈점도고절[(4.03±0.45)mPa·s 비(4.47±0.36)mPa·s,t=7.122])、홍세포압적[(39.75±4.09)%비(43.98±4.17)%,t=6.755]、섬유단백원[(3.21±0.38)g/L비(4.05±0.42)g/L,t=13.833]균명현저우대조조(P<0.01혹P<0.05).결론 자감초탕가감가개선노년관심병환자적혈액류변학,차불량반응소.
Objective To discuss the feasibility and clinical efficacy of zhigancao decoction for the treatment of senile coronary heart disease.Methods 174 cases aged more than 60 of Liaocheng municipal hospital of Traditional Chinese Medicine were divided into a control group and an observation group by the random number table method from April 2012 to April. 2014. 87 cases in the control group were treated with conventional western medicine, while 87 cases in the observation group were takenzhigancaodecoction. The clinical efficacy, changes of hemorheology in both groups were observed and compared.Results The total effective rate of angina was 67.8% in the control group and 89.7% in the observation group, with obvious difference (χ2=11.122,P=0.001). The total effective rate of electrocardiogram was 62.1% in the control group and 80.5% in the observation group, with obvious difference (χ2=14.771,P<0.01). The change of hemorheology blood viscosity (1.48 ± 0.31 mPa·s vs. 1.61 ± 0.29 mPa·s,t=2.856), whole blood viscosity ow cut (l 6.01 ± 0.85 mPa·s vs. 6.42 ± 1.34 mPa·s, t=2.410) and high cut (4.03 ± 0.45 mPa·svs. 4.47 ± 0.36 mPa·s,t=7.122), excess inventory of red blood cells(39.75 % ± 4.09 %vs.43.98 % ± 4.17 %, t=6.755), fibrinogen(3.21 ± 0.38 g/Lvs. 4.05 ± 0.42 g/L,t=13.833) in the observation group were obviously lower than the control group after treatment (P<0.05 or P<0.01).Conclusions The combination ofzhigancao decoction can obviously improve hemorheology of senile coronary heart disease. It has obvious effect with less adverse reactions, which is worth of spreading in clinic.
