CAJ | 학술논문

姜黄素具有良好的抗癌活性，但其水溶性差、中性与碱性pH条件下稳定性不足等因素限制其医学应用。另外，聚前药两亲分子( polyprodrug amphiphiles)具有载药量高、水溶性改善、纳米结构调控等优势，在抗肿瘤研究中越来越突显优势。本工作通过缩聚方法成功制备了一种姜黄素的聚前药两亲分子， Poly ( Cur-alt-TEG)，具有高载药量，提高了姜黄素的水溶性和稳定性，进一步的细胞毒性实验表明其具有良好的抗肿瘤活性。
강황소구유량호적항암활성，단기수용성차、중성여감성pH조건하은정성불족등인소한제기의학응용。령외，취전약량친분자( polyprodrug amphiphiles)구유재약량고、수용성개선、납미결구조공등우세，재항종류연구중월래월돌현우세。본공작통과축취방법성공제비료일충강황소적취전약량친분자， Poly ( Cur-alt-TEG)，구유고재약량，제고료강황소적수용성화은정성，진일보적세포독성실험표명기구유량호적항종류활성。
Curcumin has good anticancer potency, but its poor water solubility and limited stability at neutral and alka-line milieu restricted its medical application. In addition, polyprodrug amphiphiles possess the feature of high drug load-ing, improved water dispersibility, and advantages for nanostructural fabrication. In the current work, novel curcumin-based polyprodrug amphiphiles, Poly(Cur-alt-TEG), were fabricated by condensation polymerization, possessing high drug loading content, good water solubility, stability. Further cellular experiments revealed that the anticancer effect of Poly( Cur-alt-TEG) was effective.