实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
2015年
7期
47-49,50
,共4页
心肌梗死%心绞痛%硝酸酯类%抗药性%药理作用分子作用机制%综述
心肌梗死%心絞痛%硝痠酯類%抗藥性%藥理作用分子作用機製%綜述
심기경사%심교통%초산지류%항약성%약리작용분자작용궤제%종술
Myocardial infarction%Angina pectoris%Organic nitrates drugs%Drug resistance%Molecular mechanisms of pharmacological action%Review
在全球范围内，急性心肌梗死发病率、病死率均很高，硝酸酯类药物作为急性心肌梗死及心绞痛的一线治疗药物，可有效增加血管内皮细胞一氧化氮（ NO）含量及心肌血供，扩张冠状动脉，但长期持续使用可导致硝酸酯类药物耐药，进而导致其扩张血管作用减弱或消失、血管内皮细胞功能紊乱、缺血区心肌细胞存活能力降低、心肌梗死面积扩大等，因此硝酸酯类药物耐药受到越来越多学者的关注。本文就硝酸酯类药物耐药机制及临床应对策略进行综述。
在全毬範圍內，急性心肌梗死髮病率、病死率均很高，硝痠酯類藥物作為急性心肌梗死及心絞痛的一線治療藥物，可有效增加血管內皮細胞一氧化氮（ NO）含量及心肌血供，擴張冠狀動脈，但長期持續使用可導緻硝痠酯類藥物耐藥，進而導緻其擴張血管作用減弱或消失、血管內皮細胞功能紊亂、缺血區心肌細胞存活能力降低、心肌梗死麵積擴大等，因此硝痠酯類藥物耐藥受到越來越多學者的關註。本文就硝痠酯類藥物耐藥機製及臨床應對策略進行綜述。
재전구범위내，급성심기경사발병솔、병사솔균흔고，초산지류약물작위급성심기경사급심교통적일선치료약물，가유효증가혈관내피세포일양화담（ NO）함량급심기혈공，확장관상동맥，단장기지속사용가도치초산지류약물내약，진이도치기확장혈관작용감약혹소실、혈관내피세포공능문란、결혈구심기세포존활능력강저、심기경사면적확대등，인차초산지류약물내약수도월래월다학자적관주。본문취초산지류약물내약궤제급림상응대책략진행종술。
Acute myocardial infarction is a kind of worldwide diseases with high morbidity and mortality, as the first-line drugs of acute myocardial infarction and angina pectoris, organic nitrates drugs can effectively increase the NO content of vascular endothelial cell and myocardial blood flow, expand coronary artery, but long-term continuous using of organic nitrates drugs may result in drug resistance, and then induce the effect decreased or disappeared for expanding blood vessel, vascular endothelial cell dysfunction, ischemic myocardial cells survival ability decreased, myocardial infarct area enlarged and so on.In recent years, more and more people pay attentions to organic nitrates drugs resistance, this paper reviewed resistance mechanisms of organic nitrates drugs and the clinical coping strategy.
