吉林中医药
吉林中醫藥
길림중의약
Jilin Journal of Traditional Chinese Medicine
2015年
9期
897-900,901
,共5页
补肾%活血化瘀%尼莫地平%血管性痴呆%脂质代谢%补肾填精%祛瘀化痰
補腎%活血化瘀%尼莫地平%血管性癡呆%脂質代謝%補腎填精%祛瘀化痰
보신%활혈화어%니막지평%혈관성치태%지질대사%보신전정%거어화담
tonify kidney%activate blood circulation and dissipate blood stasis%nimodipine%vascular dementia%lipid metabolism%tonify kidney to fill in essence%remove blood stasis and phlegm
目的：探讨补肾活血化瘀方药联合尼莫地平在治疗轻中度血管性痴呆中的临床应用及其对脂质代谢的影响。方法选取97例经诊断为轻中度血管性痴呆患者，分为治疗组（50例）与对照组（47例），分别给予补肾活血化瘀方药联合尼莫地平治疗及单纯尼莫地平治疗。经12周的治疗后，比较2组患者治疗前后的MMSE评分及ADL评分情况，并对患者进行血脂系列指标的检测，比较TC、TG、ApoE、HDL－ch、LDL－ch在治疗前后的差异，评价2种药物治疗方式的临床疗效及对脂质代谢过程的影响。结果经过12周的药物治疗后，2组患者均出现MMSE评分升高及ADL评分降低，并且治疗组改善幅度较对照组明显增加（ P＜0.05）。血脂水平检测结果表明，2组患者血脂代谢均有改善，并且治疗组较对照组TC、TG、ApoE、LDL－ch指标均有所降低，而HDL－ch水平升高，差异具有统计学意义。结论补肾活血化瘀方药联合尼莫地平治疗轻中度血管性痴呆能够有效改善患者脂质代谢，对血脂系列指标产生有利的调节作用。
目的：探討補腎活血化瘀方藥聯閤尼莫地平在治療輕中度血管性癡呆中的臨床應用及其對脂質代謝的影響。方法選取97例經診斷為輕中度血管性癡呆患者，分為治療組（50例）與對照組（47例），分彆給予補腎活血化瘀方藥聯閤尼莫地平治療及單純尼莫地平治療。經12週的治療後，比較2組患者治療前後的MMSE評分及ADL評分情況，併對患者進行血脂繫列指標的檢測，比較TC、TG、ApoE、HDL－ch、LDL－ch在治療前後的差異，評價2種藥物治療方式的臨床療效及對脂質代謝過程的影響。結果經過12週的藥物治療後，2組患者均齣現MMSE評分升高及ADL評分降低，併且治療組改善幅度較對照組明顯增加（ P＜0.05）。血脂水平檢測結果錶明，2組患者血脂代謝均有改善，併且治療組較對照組TC、TG、ApoE、LDL－ch指標均有所降低，而HDL－ch水平升高，差異具有統計學意義。結論補腎活血化瘀方藥聯閤尼莫地平治療輕中度血管性癡呆能夠有效改善患者脂質代謝，對血脂繫列指標產生有利的調節作用。
목적：탐토보신활혈화어방약연합니막지평재치료경중도혈관성치태중적림상응용급기대지질대사적영향。방법선취97례경진단위경중도혈관성치태환자，분위치료조（50례）여대조조（47례），분별급여보신활혈화어방약연합니막지평치료급단순니막지평치료。경12주적치료후，비교2조환자치료전후적MMSE평분급ADL평분정황，병대환자진행혈지계렬지표적검측，비교TC、TG、ApoE、HDL－ch、LDL－ch재치료전후적차이，평개2충약물치료방식적림상료효급대지질대사과정적영향。결과경과12주적약물치료후，2조환자균출현MMSE평분승고급ADL평분강저，병차치료조개선폭도교대조조명현증가（ P＜0.05）。혈지수평검측결과표명，2조환자혈지대사균유개선，병차치료조교대조조TC、TG、ApoE、LDL－ch지표균유소강저，이HDL－ch수평승고，차이구유통계학의의。결론보신활혈화어방약연합니막지평치료경중도혈관성치태능구유효개선환자지질대사，대혈지계렬지표산생유리적조절작용。
Objective To explore the clinical effects and influence on lipid metabolism of herbs used to tonify kidney ,acti-vate blood circulation and dissipate blood stasis in treating vascular dementia combined with nimodipine .Methods The 97 cases of patients with mild-to-moderate vascular dementia were selected and divided into two groups according to the treat-ment .Patients in treatment group(50 cases) were treated with herbs used to tonify kidney ,activate blood circulation ,dissi-pate blood stasis and nimodipine and patients in control group(47 cases) were treated with nimodipine only .With 12 weeks’ treatment ,MMSE and ADL’s scores and the examination results of serum lipid (TC ,TG ,ApoE ,HDL-ch and LDL-ch ) were compared between two groups to evaluate herbs’ clinical effects and influence on lipid metabolism .Results With 12 weeks’ treatment ,in both two groups ,patients’ MMSE score improves and ADL score decreases and the improvement extent is signif-icantly larger in the treatment group ( P<0 .05 ) .Serum lipid examination shows that TC ,TG ,ApoE ,LDL-ch level in exper-imental group significantly decreased and HDL-ch level improved when compared with control group .Conclusion Combi-nation of herbs used to tonify kidney ,activate blood circulation and dissipate blood stasis with nimodipine has great clinical effects on treatment of mild-to-moderate vascular dementia and is advantageous in serum lipid metabolism .
