实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
2015年
7期
58-60
,共3页
心力衰竭%血管紧张素Ⅱ%利钠肽, 脑%替米沙坦
心力衰竭%血管緊張素Ⅱ%利鈉肽, 腦%替米沙坦
심력쇠갈%혈관긴장소Ⅱ%리납태, 뇌%체미사탄
Heart failure%AngiotensinⅡ%Natriuretic peptide,brain%Telmisartan
目的：探究替米沙坦治疗充血性心力衰竭（ CHF）的临床疗效及对血清血管紧张素Ⅱ（ AngⅡ）和B型脑钠肽（ BNP）水平的影响。方法选取广西南宁市第一人民医院心血管内科2011年1月—2013年1月收治的CHF患者68例，随机分为对照组和研究组，各34例。对照组患者采用常规治疗，研究组患者在常规治疗基础上给予替米沙坦治疗，两组患者均治疗6个月。比较两组患者临床疗效，治疗前后血清AngⅡ、 BNP水平及左心室舒张末期内径（ LVDd）、左心室射血分数（ LVEF），观察治疗期间研究组患者不良反应发生情况。结果研究组患者临床疗效优于对照组（P＜0.05）。治疗前两组患者血清AngⅡ、 BNP水平及LVDd、 LVEF比较，差异无统计学意义（P＞0.05）；治疗后研究组患者血清AngⅡ、 BNP水平低于对照组， LVDd大于对照组， LVEF高于对照组（ P＜0.05）。治疗期间研究组患者不良反应发生率为5.9％。结论在常规治疗基础上加用替米沙坦治疗CHF的疗效确切，能有效降低患者血清AngⅡ和BNP水平，从而改善患者心功能，且安全性较高。
目的：探究替米沙坦治療充血性心力衰竭（ CHF）的臨床療效及對血清血管緊張素Ⅱ（ AngⅡ）和B型腦鈉肽（ BNP）水平的影響。方法選取廣西南寧市第一人民醫院心血管內科2011年1月—2013年1月收治的CHF患者68例，隨機分為對照組和研究組，各34例。對照組患者採用常規治療，研究組患者在常規治療基礎上給予替米沙坦治療，兩組患者均治療6箇月。比較兩組患者臨床療效，治療前後血清AngⅡ、 BNP水平及左心室舒張末期內徑（ LVDd）、左心室射血分數（ LVEF），觀察治療期間研究組患者不良反應髮生情況。結果研究組患者臨床療效優于對照組（P＜0.05）。治療前兩組患者血清AngⅡ、 BNP水平及LVDd、 LVEF比較，差異無統計學意義（P＞0.05）；治療後研究組患者血清AngⅡ、 BNP水平低于對照組， LVDd大于對照組， LVEF高于對照組（ P＜0.05）。治療期間研究組患者不良反應髮生率為5.9％。結論在常規治療基礎上加用替米沙坦治療CHF的療效確切，能有效降低患者血清AngⅡ和BNP水平，從而改善患者心功能，且安全性較高。
목적：탐구체미사탄치료충혈성심력쇠갈（ CHF）적림상료효급대혈청혈관긴장소Ⅱ（ AngⅡ）화B형뇌납태（ BNP）수평적영향。방법선취엄서남저시제일인민의원심혈관내과2011년1월—2013년1월수치적CHF환자68례，수궤분위대조조화연구조，각34례。대조조환자채용상규치료，연구조환자재상규치료기출상급여체미사탄치료，량조환자균치료6개월。비교량조환자림상료효，치료전후혈청AngⅡ、 BNP수평급좌심실서장말기내경（ LVDd）、좌심실사혈분수（ LVEF），관찰치료기간연구조환자불량반응발생정황。결과연구조환자림상료효우우대조조（P＜0.05）。치료전량조환자혈청AngⅡ、 BNP수평급LVDd、 LVEF비교，차이무통계학의의（P＞0.05）；치료후연구조환자혈청AngⅡ、 BNP수평저우대조조， LVDd대우대조조， LVEF고우대조조（ P＜0.05）。치료기간연구조환자불량반응발생솔위5.9％。결론재상규치료기출상가용체미사탄치료CHF적료효학절，능유효강저환자혈청AngⅡ화BNP수평，종이개선환자심공능，차안전성교고。
Objective To explore the clinical effect of telmisartan on congestive heart failure and its impact on serum angiotensinⅡ (AngⅡ) and B-type natriuretic peptide (BNP) levels.Methods From January 2011 to January 2013, a total of 68 patients with congestive heart failure were selected in the Department of Cardiovasology, the First People′s Hospital of Nanning, and they were randomly divided into control group and research group, each of 34 cases.Patients of control group received conventional treatment, while patients of research group received extra telmisartan based on conventional treatment, both groups treated for 6 months.Clinical effect, serum AngⅡ and BNP levels, LVDd and LVEF before and after treatment were compared between the two groups, and incidence of adverse reactions of research group during treatment was recorded. Results The clinical effect of research group was statistically significantly better than that of control group (P<0.05).No statistically significant differences of serum AngⅡ or BNP level, LVDd or LVEF was found between the two groups before treatment ( P>0.05); after treatment, serum AngⅡand BNP levels of research group were statistically significantly lower than those of control group, LVDd of research group was statistically significantly larger than that of control group, LVEF of research group was statistically significantly higher than that of control group (P<0.05).The incidence of adverse reactions of research group was 5.9% during treatment.Conclusion Based on conventional treatment, telmisartan has certain clinical effect on congestive heart failure, which can effectively reduce the serum AngⅡand BNP levels to improve the cardiac function, is with relatively high safety.
