微生物学杂志
微生物學雜誌
미생물학잡지
Journal of Microbiology
2015年
3期
1-8
,共8页
吕淑霞%张云鹤%白玲%张林%杨宇
呂淑霞%張雲鶴%白玲%張林%楊宇
려숙하%장운학%백령%장림%양우
混菌发酵%伴生菌%普通生酮基古龙酸菌%L-山梨糖脱氢酶%2酮-基-L-古龙酸
混菌髮酵%伴生菌%普通生酮基古龍痠菌%L-山梨糖脫氫酶%2酮-基-L-古龍痠
혼균발효%반생균%보통생동기고룡산균%L-산리당탈경매%2동-기-L-고룡산
Mixed cultures fermentation%co-helper%Ketogulonicigenium vulgare%L-sorbose dehydrogenase%2-Keto-L-gulonic acid
维生素C（ Vc）二步混菌发酵是我国首创具有自主知识产权的唯一应用于工业化生产Vc的微生物转化方法，该方法利用混合菌发酵L-山梨糖生产Vc前体物质-2-酮基-L-古龙酸，再经化学转化合成Vc；具有简化工艺，减少污染，降低能耗等优点。本文主要从产酸菌代谢关键酶、伴生菌胞外物质、组学以及外源添加物等方面综述Vc二步混菌发酵的最新研究进展，并提出进一步研究和探索的方向。
維生素C（ Vc）二步混菌髮酵是我國首創具有自主知識產權的唯一應用于工業化生產Vc的微生物轉化方法，該方法利用混閤菌髮酵L-山梨糖生產Vc前體物質-2-酮基-L-古龍痠，再經化學轉化閤成Vc；具有簡化工藝，減少汙染，降低能耗等優點。本文主要從產痠菌代謝關鍵酶、伴生菌胞外物質、組學以及外源添加物等方麵綜述Vc二步混菌髮酵的最新研究進展，併提齣進一步研究和探索的方嚮。
유생소C（ Vc）이보혼균발효시아국수창구유자주지식산권적유일응용우공업화생산Vc적미생물전화방법，해방법이용혼합균발효L-산리당생산Vc전체물질-2-동기-L-고룡산，재경화학전화합성Vc；구유간화공예，감소오염，강저능모등우점。본문주요종산산균대사관건매、반생균포외물질、조학이급외원첨가물등방면종술Vc이보혼균발효적최신연구진전，병제출진일보연구화탐색적방향。
wo-step mixed cultures fermentation initiatively established with independent intellectual property rights is a microbial transformation method used in vitamin C industrial production in China.2-keto-L-gulonic acid (2-KGA)-the precursor of Vitamin C is transformed from L-sorbose through the mixed cultures fermentation which has the advan-tages of simple operation, less pollution and lower energy consumption.In this paper, the latest new progresses of mixed cultures fermentation producing 2-KGA are reviewed from the aspects of key enzymes of Ketogu lno icigenium vul-gare, extracellular substances of co-helper, Omics and exogenous additives.Meanwhile the prospective research fields are also mentioned in order to provide some references for the researchers.
