CAJ | 학술논문

光声显微成像技术依赖于样品的内源性光吸收，对强散射弱吸收样品成像效果差，甚至无法进行成像。为了实现强散射弱吸收高透明生物样品的光声显微成像，以及获得图像的边缘增强效果，使光声显微成像技术在实际的生物医学研究中更有应用价值，本文首次将散射光声技术引入到光声微分显微技术中，研制了新型的散射光声微分成像技术。该技术不仅可以获得强散射弱吸收高透明生物样品的散射光声显微图像，还可以获得对应的边缘清晰的散射光声微分图像，对在生物医学研究领域有重要的应用意义。
광성현미성상기술의뢰우양품적내원성광흡수，대강산사약흡수양품성상효과차，심지무법진행성상。위료실현강산사약흡수고투명생물양품적광성현미성상，이급획득도상적변연증강효과，사광성현미성상기술재실제적생물의학연구중경유응용개치，본문수차장산사광성기술인입도광성미분현미기술중，연제료신형적산사광성미분성상기술。해기술불부가이획득강산사약흡수고투명생물양품적산사광성현미도상，환가이획득대응적변연청석적산사광성미분도상，대재생물의학연구영역유중요적응용의의。
Depending on endogenous optical absorption of sample, photoacoustic microscopy for the strong scattering weak absorbing sample is difficult. In order to realize the photoacoustic microscopy of strong scattering weak absorbing biological sample, and obtain the edge enhancement image, which make the photoacoustic microscopy technique has meaningful application value in biomedical research, this paper firstly combine the scattering photoacoustic technique with the photoacoustic differential microscopy and develop a novel scattering photoacoustic differential imaging technique. This technique can not only obtain scattering photoacoustic microscopic images of strong scattering weak absorbing biolog-ical sample, but also obtain the corresponding scattering photoacoustic differential images with clear edge. This tech-nique has important application significance in the field of biomedical research.