CAJ | 학술논문

去甲斑蝥素（ NCTD）是斑蝥素的重要衍生物，其毒性低，药理作用明确，无骨髓抑制等不良反应，在治疗癌症及疑难杂症方面具有独特疗效。近年有研究发现，NCTD可降低肾病大鼠尿蛋白水平，通过多种机制减轻肾间质纤维化，可能在治疗免疫相关性肾病及防治肾间质纤维化方面具有良好的应用价值。该文对NCTD的药理作用机制及其在肾脏病领域中的应用前景作一综述。
거갑반모소（ NCTD）시반모소적중요연생물，기독성저，약리작용명학，무골수억제등불량반응，재치료암증급의난잡증방면구유독특료효。근년유연구발현，NCTD가강저신병대서뇨단백수평，통과다충궤제감경신간질섬유화，가능재치료면역상관성신병급방치신간질섬유화방면구유량호적응용개치。해문대NCTD적약리작용궤제급기재신장병영역중적응용전경작일종술。
Norcantharidin ( NCTD) , an important derivative of cantharidin , has distinctive therapeutic effects on cancers and some incurable diseases .Norcantharidin has low toxicity and clear pharmacological effects without bone marrow suppression and other adverse reactions .Recently , some studies showed that NCTD could not only re-duce urinary protein of rats with renal diseases , but also protect renal tubulointerstitial fibrosis by multiple mecha-nisms.NCTD may have a good value of application on immune-related nephropathy and renal interstitial fibrosis pre-vention.The pharmacological mechanism of NCTD and its potential treatment of renal diseases are reviewed in this paper .