CAJ | 학술논문

先进的光学纳米探针对于生物组织的光学成像、疾病的诊断和治疗具有巨大的促进作用，尤其是对于生物体分子水平活动的动态信息的深入了解。新型的光学探针如纳米金棒、上转换纳米颗粒和氧化石墨烯等，能克服传统探针的一些不足，具有较高的对比度、稳定性和生物兼容性，而且还拥有深层组织成像和实时动态成像的能力。本文对这些纳米光学探针的光学性质和优点进行了简要的介绍，并通过综述作者及其他研究者在过去几年的研究成果，总结这些先进的纳米探针在生物成像和医学诊断、治疗方面的应用，并展望其应用前景。
선진적광학납미탐침대우생물조직적광학성상、질병적진단화치료구유거대적촉진작용，우기시대우생물체분자수평활동적동태신식적심입료해。신형적광학탐침여납미금봉、상전환납미과립화양화석묵희등，능극복전통탐침적일사불족，구유교고적대비도、은정성화생물겸용성，이차환옹유심층조직성상화실시동태성상적능력。본문대저사납미광학탐침적광학성질화우점진행료간요적개소，병통과종술작자급기타연구자재과거궤년적연구성과，총결저사선진적납미탐침재생물성상화의학진단、치료방면적응용，병전망기응용전경。
The employment of nanometric optical probes is powerful for bioimaging, disease diagnosis and therapy, es-pecially for the deep understanding of some dynamic biological processes at the molecular level. Optical probes such as gold nanorods (GNRs), upconversion nanoparticles (UCNPs) and graphene oxide (GO) can overcome many draw-backs of conventional optical agents. These nanoparticles possess high imaging contrast, stability and biocompatibility. Furthermor, they provide optical approaches for deep-tissue imaging and real-time dynamic imaging. In this review pa-per, the optical properties and advantages of these nanoparticles are briefly introduced, and some of their applications in optical bioimaging, diagnosis and therapy are summarized based on some of the research progress made by the authors and others. The prospects of their application are also discussed.