CAJ | 학술논문

血管中的血氧饱和度( Oxygen saturation,StO2)作为影响血管靶向光动力疗法( Vascular targeted photo-dynamic therapy,V-PDT)疗效的关键要素之一,实验测量了活体裸鼠背皮窗模型中血管的漫反射光谱(450-800 nm),并通过拟合漫反射光谱数据定量获得了血管中的StO2。同时,研究了高氧、低氧和常氧等三种不同氧条件下V-PDT中血管的StO2和血管管径的变化情况。结果表明,高氧和常氧条件下的平均StO2和血管收缩较为显著,但低氧组的平均StO2和血管收缩不明显。在相同氧条件和不同光照功率密度条件下,V-PDT前后靶向血管的平均StO2与血管管径的变化之间没有显著相关性,但V-PDT前后平均StO2的变化量与光照功率密度之间呈正相关。
혈관중적혈양포화도( Oxygen saturation,StO2)작위영향혈관파향광동력요법( Vascular targeted photo-dynamic therapy,V-PDT)료효적관건요소지일,실험측량료활체라서배피창모형중혈관적만반사광보(450-800 nm),병통과의합만반사광보수거정량획득료혈관중적StO2。동시,연구료고양、저양화상양등삼충불동양조건하V-PDT중혈관적StO2화혈관관경적변화정황。결과표명,고양화상양조건하적평균StO2화혈관수축교위현저,단저양조적평균StO2화혈관수축불명현。재상동양조건화불동광조공솔밀도조건하,V-PDT전후파향혈관적평균StO2여혈관관경적변화지간몰유현저상관성,단V-PDT전후평균StO2적변화량여광조공솔밀도지간정정상관。
Monitoring oxygen saturation changes during vasculartargeted photodynamic therapy ( V-PDT) is crucial for achieving an optimal therapeutic outcome. In this study, the diffuse reflection spectra in the range from 450 to 800 nm were measured to quantitatively determine oxygen saturation ( StO2 ) of blood vessels in dorsal skinfold window chamber. Furthermore, the changes of the average StO2 and vasoconstriction of blood vessels in the region of interest ( ROI) after V-PDT was evaluated when the nude mice breathing either hypoxic, normoxic, or hyperoxic air under normobaric condi-tions, respectively. The average StO2 and vasoconstriction of blood vessels for normoxic and hyperoxic groups after V-PDT was dramatically changed while no significant change was found for those of blood vessels in hypoxic group. No con-sistent pattern for the changes of StO2 and vasoconstriction during V-PDT treatment can be observed. However, the V-PDT-induced change in StO2 was positively correlated with various irradiances.