CAJ | 학술논문

低氧培养能影响间充质干细胞( Mesenchymal stem cells, MSCs)细胞活力、增殖能力、衰老、死亡等生存和生长相关特性,其分子机制复杂多重,涉及能量代谢途径、低氧诱导因子( HIFs)信号通路以及诸多其他信号通路、调控和转导分子。目前受限于MSCs来源、分离纯化方法、筛选标记以及低氧体系构建方法等因素,低氧培养对MSCs的影响结果还无法做统一性的概括。综述现有研究结果,为今后最佳MSCs培养体系构建,以及MSCs的临床应用研究奠定基础。
저양배양능영향간충질간세포( Mesenchymal stem cells, MSCs)세포활력、증식능력、쇠로、사망등생존화생장상관특성,기분자궤제복잡다중,섭급능량대사도경、저양유도인자( HIFs)신호통로이급제다기타신호통로、조공화전도분자。목전수한우MSCs래원、분리순화방법、사선표기이급저양체계구건방법등인소,저양배양대MSCs적영향결과환무법주통일성적개괄。종술현유연구결과,위금후최가MSCs배양체계구건,이급MSCs적림상응용연구전정기출。
Cultruing mesenchymal stem cells ( MSCs) under hypoxia condition could influence their characteristics of survival and growth, such as vitality, proliferation, senesce, dealth, and so on. The mechanism of MSCs resistance/sensitivity to hypoxia impact is complex and multiple. It involves in energy metabolism, HIFs signal pathway and others signal pathways and kinds of molecules of regulation or transduction. Because of the difference of MSCs source, the methods of isolation, the cell surface markers, the way of establishing hypoxia environment and others methodological fac-tors. It seems that the currently available experimental data on hypoxia impact to MSCs are so contradictory. It is necessary to summarize recent researches on the survival and the growth of MSCs under low oxygen conditions in order to lay the foun-dation for establishing the best culture system of MSCs in future and the research of the clinical application of MSCs.