CAJ | 학술논문

目的：探讨儿童新型抗癫痫药物口服过量的不良反应特点，促进安全用药。方法以2例分别口服奥卡西平和拉莫三嗪过量的儿童患者为例，结合文献报道阐述其中毒后的主要临床表现、实验室指标、治疗过程及预后。结果与结论本研究中2例分别口服奥卡西平和拉莫三嗪过量中毒病例的临床表现主要以呕吐和腹痛等胃肠道症状为主，嗜睡和呼吸抑制相对于传统抗癫痫药（如卡马西平、苯巴比妥等）较轻。及时采取对症治疗后2例患者预后均较为良好。临床需注意做好鉴别诊断和血药浓度监测。
목적：탐토인동신형항전간약물구복과량적불량반응특점，촉진안전용약。방법이2례분별구복오잡서평화랍막삼진과량적인동환자위례，결합문헌보도천술기중독후적주요림상표현、실험실지표、치료과정급예후。결과여결론본연구중2례분별구복오잡서평화랍막삼진과량중독병례적림상표현주요이구토화복통등위장도증상위주，기수화호흡억제상대우전통항전간약（여잡마서평、분파비타등）교경。급시채취대증치료후2례환자예후균교위량호。림상수주의주호감별진단화혈약농도감측。
Objective To investigate the adverse drug reactions character-istics of cases with children′s newer antiepileptic drugs ( AEDs ) over-dose, and to promote medication safety.Methods The main clinical manifestation, laboratory indexes, therapeutic process and prognosis fol-lowing oxcarbazepine and lamotrigine overdose were reviewed in this study with two example cases and relative reports.Results and Conclusion The main clinical manifestation of patients following oxcar-bazepine and lamotrigine overdose respectively observed in this study was abdominal discomfort as vomiting and stomachache, however somnolence and respiratory depression were relatively slighter than traditional AEDs ( such as carbamazepine and phenobarbital ).After taking symptomatic treatment in time, both of the two poisoning cases had good prognosis.Clinician should be careful of the differential diagnosis and strengthen therapeutic drug monitoring.