CAJ | 학술논문

目的：探讨灯盏细辛注射液临床使用合理性与安全性再评价问题。方法采取分层随机法抽取某医院2013年1至12月份使用灯盏细辛注射液住院病历120份，通过药品说明书推荐及药物利用研究，探讨灯盏细辛注射剂临床使用合理性与安全性再评价研究模式。结果该医院2013年灯盏细辛注射液临床使用中医辨病（34.17％）、中医辨证（18.33％）、溶媒剂量（35.83％）及给药浓度（2.50％）合理性百分率普遍偏低，8，7，6项指标合理性总得分百分率平均值亦不高（53.96％，56.55％，49.31％），尤其超浓度使用情况严重（aDDCs＝28.09， cDUI＝2.93＞1）。结论应加强灯盏细辛注射液临床监测工作。
목적：탐토등잔세신주사액림상사용합이성여안전성재평개문제。방법채취분층수궤법추취모의원2013년1지12월빈사용등잔세신주사액주원병력120빈，통과약품설명서추천급약물이용연구，탐토등잔세신주사제림상사용합이성여안전성재평개연구모식。결과해의원2013년등잔세신주사액림상사용중의변병（34.17％）、중의변증（18.33％）、용매제량（35.83％）급급약농도（2.50％）합이성백분솔보편편저，8，7，6항지표합이성총득분백분솔평균치역불고（53.96％，56.55％，49.31％），우기초농도사용정황엄중（aDDCs＝28.09， cDUI＝2.93＞1）。결론응가강등잔세신주사액림상감측공작。
Objective To explore the method of research on the rationality and safety of traditional Chinese medicine injections ( TCMIs) in clinical use, such as Dengzhanxixin injections.Methods In this study, 120 medical records from the certain hospital, which contained Dengzhanxixin injections prescription during 2013 , were selected randomly and evalua-ted by instructions recommendation and drug utilization research ( DUR) .Results There were poor rationality and safety, such as in disease and syndrome differentiation of traditional Chinese medicine (34.17%and 18.33%for rationality, respectively), the solvent volume (35.83%for rationality), the administration concentration (2.50% for rationality) of Dengzhanxixin injections.The six or seven or eight param-eters total scores were 53.96%, 56.55%, 49.31% for rationality, respectively and there was super-concentration administration ( average defined daily concentration 28.09 and drug utilization index 2.93 ).Conclusion In brief, it should strengthen to monitor Dengzhanxixin injections in clinical use.