CAJ | 학술논문

蛋白质的O－甘露糖基化修饰不仅在真菌和哺乳类细胞中广泛存在，在原核生物中例如分枝杆菌属、棒状杆菌属和链霉菌属中也存在，尤其在引起人类疾病的结核分枝杆菌中研究最多。许多O－甘露糖基化蛋白在结核分枝杆菌毒力以及与宿主相互作用过程中发挥了重要作用。本文就结核分枝杆菌中O－甘露糖基化蛋白生物学功能的进展加以综述。
단백질적O－감로당기화수식불부재진균화포유류세포중엄범존재，재원핵생물중례여분지간균속、봉상간균속화련매균속중야존재，우기재인기인류질병적결핵분지간균중연구최다。허다O－감로당기화단백재결핵분지간균독력이급여숙주상호작용과정중발휘료중요작용。본문취결핵분지간균중O－감로당기화단백생물학공능적진전가이종술。
O-mannosylation decoration of proteins not only widely exists in fungal and mammalian cells, but also ex-ists in prokaryotes, e.g.Mycobacterium, Corynebaterium and Streptomyces, especially in Mycobacterium tuberculosis that causes human illness and draw studies the most.Many O-mannosylated proteins play important role during mutual actions in M.tuberculosis virulence and the host.Advances in biological function of O-mannosylated proteins in M. tuberculosis were summarized in this paper.