CAJ | 학술논문

目的：探讨附子临床应用中出现不良反应的影响因素。方法选取2013-01～2014-08该院收治的确诊为寒湿痹阻型痹证采用中医复方治疗的患者240例为研究对象，根据复方有无附子分为A组和B组各120例，A组给予未加附子复方治疗，B组给予附子复方治疗，观察两组的临床不良反应情况。结果 A组发生不良反应16例（13.33％），B组发生不良反应60例（50.00％），两组差异有统计学意义（χ2＝32.28，P＝0.000）。 B组120例患者中，有不良反应组先煎时间与煎煮总时间（min）均明显短于无不良反应组[（36.5±4.23） vs （31.46±3.16），P＝0.000；（89.75±1.52） vs （86.36±2.42），P＝0.000]；平均使用剂量（g）也明显高于无不良反应组[（24.15±6.26） vs （20.53±3.52），t＝16.712，P＝0.017]。结论附子的先煎时间、煎煮总时间及其使用剂量均是影响其临床不良反应的因素。
목적：탐토부자림상응용중출현불량반응적영향인소。방법선취2013-01～2014-08해원수치적학진위한습비조형비증채용중의복방치료적환자240례위연구대상，근거복방유무부자분위A조화B조각120례，A조급여미가부자복방치료，B조급여부자복방치료，관찰량조적림상불량반응정황。결과 A조발생불량반응16례（13.33％），B조발생불량반응60례（50.00％），량조차이유통계학의의（χ2＝32.28，P＝0.000）。 B조120례환자중，유불량반응조선전시간여전자총시간（min）균명현단우무불량반응조[（36.5±4.23） vs （31.46±3.16），P＝0.000；（89.75±1.52） vs （86.36±2.42），P＝0.000]；평균사용제량（g）야명현고우무불량반응조[（24.15±6.26） vs （20.53±3.52），t＝16.712，P＝0.017]。결론부자적선전시간、전자총시간급기사용제량균시영향기림상불량반응적인소。
Objective To explore the influence factors of adverse reactions on the clinical application of aco -nite root.Methods 240 patients who received the therapy of traditional Chinese medicine (TCM) were selected as the research objects and were randomly divided into two groups .Group A was given the treatment of TCM compounds without aconite root ( n=120 ) , while group B was given the matched prescriptions with aconite root ( n=120 ) .The clinical adverse reactions were compared between the two groups .Results There were 16 cases(13.33%) with ad-verse reactions in group A, and 60 cases (50.00%) in group B, with a significant difference (χ2 =32.28, P=0.000 ) .Among 120 patients of group B , the first decoction time and the total decoction time were significantly shor-ter in the subgroup of adverse reactions than those in the subgroup of non-adverse reactions [ ( 36.5 ±4.23 ) min vs (31.46 ±3.16)min, P=0.000;(89.75 ±1.52)min vs (86.36 ±2.42)min, P=0.000].The mean dose of the subgroup of adverse reactions was significantly higher than that of the subgroup of non -adverse reactions [ ( 24.15 ± 6.26) vs (20.53 ±3.52), t=16.712, P=0.017].Conclusion Decoction time of aconite root and its dosage are the factors that affect the clinical adverse reactions .