中国医院用药评价与分析
中國醫院用藥評價與分析
중국의원용약평개여분석
Evaluation and Analysis of Drug-Use in Hospitals of China
2015年
9期
1171-1172,1173
,共3页
周丘%王芳琴%许方荣%戴仕兰
週丘%王芳琴%許方榮%戴仕蘭
주구%왕방금%허방영%대사란
麻醉分析%围麻醉期%高血压%右美托咪定
痳醉分析%圍痳醉期%高血壓%右美託咪定
마취분석%위마취기%고혈압%우미탁미정
Narcoanalysis%Perianesthesia care%Hypertension%Dexmedetomidine
目的：探讨老年高血压病患者围麻醉期应用小剂量右美托咪定控制血压的临床效果及安全性。方法：选择抚州市临川区人民医院2013年4月—2014年4月行前列腺电切术的高血压病患者120例，根据随机数字表法分为观察组和对照组各60例，观察组患者给予以小剂量右美托咪定静脉泵注麻醉，对照组患者给予咪达唑仑静脉滴注麻醉，比较2组患者围麻醉期不同时间点的心率、平均动脉压、中心静脉压、血氧饱和度等各项指标变化及不良反应发生情况。结果：观察组患者给药后10 min、麻醉后1 h、麻醉后2 h，术中心率、平均动脉压、中心静脉压、血氧饱和度等各项指标显著优于对照组，差异有统计学意义（ P＜0.05）；观察组患者的不良反应发生率为13.33％（8／60），显著低于对照组的40.00％（24／60），差异有统计学意义（P＜0.05）。结论：老年高血压病患者围麻醉期应用小剂量右美托咪定，可有效控制血压，患者生命体征平稳，不良反应少，值得临床推广。
目的：探討老年高血壓病患者圍痳醉期應用小劑量右美託咪定控製血壓的臨床效果及安全性。方法：選擇撫州市臨川區人民醫院2013年4月—2014年4月行前列腺電切術的高血壓病患者120例，根據隨機數字錶法分為觀察組和對照組各60例，觀察組患者給予以小劑量右美託咪定靜脈泵註痳醉，對照組患者給予咪達唑崙靜脈滴註痳醉，比較2組患者圍痳醉期不同時間點的心率、平均動脈壓、中心靜脈壓、血氧飽和度等各項指標變化及不良反應髮生情況。結果：觀察組患者給藥後10 min、痳醉後1 h、痳醉後2 h，術中心率、平均動脈壓、中心靜脈壓、血氧飽和度等各項指標顯著優于對照組，差異有統計學意義（ P＜0.05）；觀察組患者的不良反應髮生率為13.33％（8／60），顯著低于對照組的40.00％（24／60），差異有統計學意義（P＜0.05）。結論：老年高血壓病患者圍痳醉期應用小劑量右美託咪定，可有效控製血壓，患者生命體徵平穩，不良反應少，值得臨床推廣。
목적：탐토노년고혈압병환자위마취기응용소제량우미탁미정공제혈압적림상효과급안전성。방법：선택무주시림천구인민의원2013년4월—2014년4월행전렬선전절술적고혈압병환자120례，근거수궤수자표법분위관찰조화대조조각60례，관찰조환자급여이소제량우미탁미정정맥빙주마취，대조조환자급여미체서륜정맥적주마취，비교2조환자위마취기불동시간점적심솔、평균동맥압、중심정맥압、혈양포화도등각항지표변화급불량반응발생정황。결과：관찰조환자급약후10 min、마취후1 h、마취후2 h，술중심솔、평균동맥압、중심정맥압、혈양포화도등각항지표현저우우대조조，차이유통계학의의（ P＜0.05）；관찰조환자적불량반응발생솔위13.33％（8／60），현저저우대조조적40.00％（24／60），차이유통계학의의（P＜0.05）。결론：노년고혈압병환자위마취기응용소제량우미탁미정，가유효공제혈압，환자생명체정평은，불량반응소，치득림상추엄。
OBJECTIVE:To probe into the clinical efficacy and safety of low-dose dexmedetomidine in blood pressure control for elderly patients with hypertension during perianesthesia care .METHODS:120 elderly patients with hypertension that received the prostate electrocision in People's Hospital of Fuzhou Linchuan Distinct from Apr .2013 to Apr.2014 were selected and then divided into Observation group and control group via random number table , with 60 cases in each group .The Observation group received the intravenous infusion of low-dose dexmedetomidine , and the control group adopted the intravenous drip of midazolam .The parameter indexes in terms of heart rate , mean arterial pressure , central venous pressure and saturation of blood oxygen of two groups at different time points of perianesthesia care were compared; and adverse reactions in two groups were evaluated .RESULTS: The indexes of HR, MAP, CVP and SaO2 of Observation group before anesthesia induction , after 10 minutes of drug administration , 1 h of anesthesia and 2 h of anesthesia were significantly better than that of control group , with statistically significant difference ( P<0.05 ) .The incidence of adverse reactions of Observation group was 13.33%( 8/60 ) , significantly lower than that of control group 40.00% ( 24/60 ) , with statistically significant difference ( P <0.05 ) . CONCLUSIONS:For elderly patients with hypertension , the low-dose dexmedetomidine can effectively control the blood pressure , maintain the stability of vital signs during perianesthesia care and has fewer reactions .The reliable and safe treatment is worthy of clinical popularization and application .
