CAJ | 학술논문

目的：探讨肺保护性通气治疗急性呼吸窘迫综合征（ ARDS）的临床疗效。方法将62例ARDS患者随机分为两组，其中对照组30例给予常规机械通气治疗，观察组32例给予肺保护性通气治疗，比较两组患者血氧分压（ PaO2）、二氧化碳分压（ PaCO2）、氧合指数（ PaO2／FiO2）的变化情况以及带机时间、住院时间、呼吸机相关肺损伤（ VALI）的发生率等。结果观察组患者经通气后8 h、24 h、48 h的PaO2、PaCO2、PaO2／FiO2均明显高于对照组（P＜0.05），带机时间和住院时间均明显短于对照组（P＜0.05），VALI发生率也明显低于对照组（ P＜0.05）。结论肺保护性通气能明显改善氧合，缩短带机时间和住院时间，减少VALI发生，对ARDS的临床救治具有重要意义。
목적：탐토폐보호성통기치료급성호흡군박종합정（ ARDS）적림상료효。방법장62례ARDS환자수궤분위량조，기중대조조30례급여상규궤계통기치료，관찰조32례급여폐보호성통기치료，비교량조환자혈양분압（ PaO2）、이양화탄분압（ PaCO2）、양합지수（ PaO2／FiO2）적변화정황이급대궤시간、주원시간、호흡궤상관폐손상（ VALI）적발생솔등。결과관찰조환자경통기후8 h、24 h、48 h적PaO2、PaCO2、PaO2／FiO2균명현고우대조조（P＜0.05），대궤시간화주원시간균명현단우대조조（P＜0.05），VALI발생솔야명현저우대조조（ P＜0.05）。결론폐보호성통기능명현개선양합，축단대궤시간화주원시간，감소VALI발생，대ARDS적림상구치구유중요의의。
Objective To evaluate the clinical effect of lung protective ventilation strategies on acute respira -tory distress syndrome ( ARDS) .Methods 62 patients with acute respiratory distress syndrome were randomly divid-ed into the control group(n=30) and the observation group(n=32).The control group was treated with convention-al ventilation strategy , and the observation group was treated with lung protective ventilation strategies .PaO2 , PaCO2 , PaCO2/FiO2 and ventilation time, hospitalization days and the rate of ventilator associated lung injury (VALI) were compared between the two groups .Results PaO2 , PaCO2 and PaO2/FiO2 at 8 h, 24 h and 48 h after ventilation in the observation were signigicantly higher than those in the control group ( P<0.05 ) .The ventilation time , hospitali-zation days and the rate of VALI in the observation group were signigicantly shorter or lower than those in the control group(P<0.05).Conclusion Using lung protective ventilation strategies for acute respiratory distress syndrome can signigicantly shorten the ventilation time , hospitalization days and reduce the incidence of VALI .It has important clinical significance for ARDS .