CAJ | 학술논문

目的：观察喘平滴丸对Beagle犬的急性毒性和长期毒性反应。方法急性毒性实验：用近似致死剂量法对Beagle犬进行急性毒性实验，观察包括一般临床观察、体重、摄食状况、血压、心电图、尿液检查、血液学检查、血液生化学检查及病理学检查。长期毒性实验：喘平滴丸以低、中、高3个剂量实验组（生药0.13，0.40，1.19 g· kg－1· d－1）和空心胶囊对照组，对Beagle犬灌胃给药，观察指标包括一般生理指标、血液学指标、血液生化指标、尿液检查、心电图、血压、眼科检查及病理学检查。结果喘平滴丸对Beagle犬单次灌胃给药的近似致死剂量大于生药54.79 g· kg－1，喘平滴丸对Beagle犬经口给药90 d的相对安全剂量为生药0.40 g· kg－1· d－1以下。结论喘平滴丸在临床剂量下服用是安全可靠的。
목적：관찰천평적환대Beagle견적급성독성화장기독성반응。방법급성독성실험：용근사치사제량법대Beagle견진행급성독성실험，관찰포괄일반림상관찰、체중、섭식상황、혈압、심전도、뇨액검사、혈액학검사、혈액생화학검사급병이학검사。장기독성실험：천평적환이저、중、고3개제량실험조（생약0.13，0.40，1.19 g· kg－1· d－1）화공심효낭대조조，대Beagle견관위급약，관찰지표포괄일반생리지표、혈액학지표、혈액생화지표、뇨액검사、심전도、혈압、안과검사급병이학검사。결과천평적환대Beagle견단차관위급약적근사치사제량대우생약54.79 g· kg－1，천평적환대Beagle견경구급약90 d적상대안전제량위생약0.40 g· kg－1· d－1이하。결론천평적환재림상제량하복용시안전가고적。
Objective To observe the acute toxicity and long -term toxicity induced by Chuanping dropping pills in beagle dogs.Methods Acute toxicity test:it was used by the approximate lethal dose on Beagle dogs.Observational index included general clinical observation, weight, ingestion capacity, blood pressure, electrocardiogram, urinalysis, blood test, blood biochemical examination and pathological examination.Long-term toxicity test:Chuanping dropping pills with 0.13, 0.40, 1.19 g · kg-1 · d-1 and the hollow capsules control group in Beagle dogs were lavaged.Observational index included general physiological indices, blood test,blood biochemical examination, urinalysis, electrocardiogram, blood pressure, eye test and pathological examination.Results The approxi-mate lethal dose in beagle dogs lavaged by Chuanping dropping pills was more than 54.79 g · kg-1.Relativel safe dose in Beagle dogs lavaged by Chuanping dropping pills after 90 days was below 0.40 g · kg-1 · d-1.Conclusion Clinical dose of Chuanping dropping pills was safe and reliable.