CAJ | 학술논문

目的：探讨姜黄素对糖尿病肾病大鼠的肾内转化生长因子表达的影响。方法采用一次性腹腔注射链脲佐菌素58 mg· kg－1（5.8 mL· kg－1）建立糖尿病肾病大鼠模型。实验组灌胃姜黄素混悬液200 mg· kg－1，正常组与模型组则灌服等体积的1％羟甲基纤维素钠。用免疫组化法观察肾小球、肾小管区域转化生长因子的表达。结果与模型组比较，实验组大鼠24 h尿微量白蛋白、空腹血糖、血浆转化生长因子的含量均明显降低（P＜0.01），肾小球、肾小管区域转化生长因子的表达也有显著降低（ P＜0.01）。结论姜黄素能下调转化生长因子在血清及肾的表达，对糖尿病肾病大鼠的肾有一定的保护作用。
목적：탐토강황소대당뇨병신병대서적신내전화생장인자표체적영향。방법채용일차성복강주사련뇨좌균소58 mg· kg－1（5.8 mL· kg－1）건립당뇨병신병대서모형。실험조관위강황소혼현액200 mg· kg－1，정상조여모형조칙관복등체적적1％간갑기섬유소납。용면역조화법관찰신소구、신소관구역전화생장인자적표체。결과여모형조비교，실험조대서24 h뇨미량백단백、공복혈당、혈장전화생장인자적함량균명현강저（P＜0.01），신소구、신소관구역전화생장인자적표체야유현저강저（ P＜0.01）。결론강황소능하조전화생장인자재혈청급신적표체，대당뇨병신병대서적신유일정적보호작용。
Objective To study effect of curcumin on expression of transforming growth factor in rats with diabetic kidney nephropathy.Methods The use of a single intraperitoneal injection of streptozotocin 58 mg · kg -1 to establish diabetic nephropathy in rats.Experimental group were given curcumin suspension 200 mg· kg-1 gavage, the normal group and model group were given equal 1%sodium carboxymethylcellu-lose volume.Observed by immunohistochemical staining of glomerular tubular regional expression of transforming growth factor.Results Com-pared with the model group, the rats of the experimental group 24 h urinary albumin, fasting blood glucose, serum transforming growth factor levels were significantly decreased (P<0.01).The glomerular, tubular region of transforming growth factor expression also decreased significantly ( P<0.01).Conclusion Curcumin can decrease the level of transfor-ming growth factor in serum and renal expression, and it has certain protective effect on diabetic nephropathy rats kidney.