CAJ | 학술논문

目的：探讨胰岛素泵联合二甲双胍、阿卡波糖与单纯胰岛素泵强化治疗对2型糖尿病的临床疗效及安全性。方法将100例2型糖尿病患者随机分为胰岛素泵联合二甲双胍、阿卡波糖治疗组（A组)和胰岛素泵治疗组(B组)，连续治疗2周后评价两组临床疗效。结果强化治疗后，两组空腹血糖及餐后两小时血糖均明显下降。A组空腹血糖、餐后两小时血糖比B组控制更佳。A组血糖达标人数多于B组，血糖达标时间较B组提前，胰岛素日用量少于B组，胰岛素停用人数多于B组。A组出现低血糖反应人数明显少于B组，两组比较有显著性差异(P<0.05)。结论胰岛素泵联合二甲双胍治疗、阿卡波糖治疗2型糖尿病比单纯胰岛素泵能更好地控制血糖，减少胰岛素需求，减少低血糖发生，安全性更高。
목적：탐토이도소빙연합이갑쌍고、아잡파당여단순이도소빙강화치료대2형당뇨병적림상료효급안전성。방법장100례2형당뇨병환자수궤분위이도소빙연합이갑쌍고、아잡파당치료조（A조)화이도소빙치료조(B조)，련속치료2주후평개량조림상료효。결과강화치료후，량조공복혈당급찬후량소시혈당균명현하강。A조공복혈당、찬후량소시혈당비B조공제경가。A조혈당체표인수다우B조，혈당체표시간교B조제전，이도소일용량소우B조，이도소정용인수다우B조。A조출현저혈당반응인수명현소우B조，량조비교유현저성차이(P<0.05)。결론이도소빙연합이갑쌍고치료、아잡파당치료2형당뇨병비단순이도소빙능경호지공제혈당，감소이도소수구，감소저혈당발생，안전성경고。
Objective To compare the effectiveness of insulin pump combining with metformin and acarbose to intensive insulin therapy for patients with type 2 diabetes mellitus.Methods 100 patients with type 2 diabetes melIitus were divided into randomly receive insulin pump combining with metformin and acarbose group (n=50) (Group A) or intensive insulin therapy group (n=50) (Group B).Results Both groups’FPG and 2h PG lowered obviously. But Group A’s FPG and 2h PG controlled better than Group B in number, time and insulin usage. Patients with reactive hypoglycemia in Group A was also less than Group B. Conclusion In treatment of type 2 diabetes mellitus, insulin pump combining with metformin and acarbose is better than intensive insulin therapy. It could control blood sugar better, reduce insulin usage and avoid reactive hypoglycemia distinctly.