CAJ | 학술논문

目的：评价益智治呆方联合吡拉西坦治疗老年痴呆症的临床疗效及其对记忆力的影响。方法114例老年痴呆症患者随机分为试验组57例和对照组57例。对照组口服吡拉西坦片0.8～1.6 g，每天4次；试验组在对照组的基础上服用益智治呆方，每天1剂，分2次服用，2组均4周为1个疗程。治疗前和连续治疗3个月后对其进行简易智能量表（ MMSE）和巴氏指数（ BI）评定，并对患者进行认知功能、记忆力和Blessed痴呆量表评估。观察2组患者的临床疗效和不良反应发生情况。结果试验组的总有效率为94.74％，显著高于对照组的63.15％（P＜0.05）。治疗后，试验组的MMSE和BI评分分别为（22.2±2.3），（85.8±5.9），显著高于对照组的（17.5±2.1），（74.9±5.7）（P＜0.05）。治疗后，试验组的认知功能、词汇记忆均显著高于对照组（P＜0.05）。试验组Blessed痴呆量表评分（4.6±2.4）低于对照组患者评分（5.8±2.5）。试验组不良反应发生率为7.01％，显著低于对照组的28.07％（ P＜0.05）。结论益智治呆方联合吡拉西坦可有效改善老年痴呆症患者临床症状，提高患者记忆力和生活能力，安全性高。
목적：평개익지치태방연합필랍서탄치료노년치태증적림상료효급기대기억력적영향。방법114례노년치태증환자수궤분위시험조57례화대조조57례。대조조구복필랍서탄편0.8～1.6 g，매천4차；시험조재대조조적기출상복용익지치태방，매천1제，분2차복용，2조균4주위1개료정。치료전화련속치료3개월후대기진행간역지능량표（ MMSE）화파씨지수（ BI）평정，병대환자진행인지공능、기억력화Blessed치태량표평고。관찰2조환자적림상료효화불량반응발생정황。결과시험조적총유효솔위94.74％，현저고우대조조적63.15％（P＜0.05）。치료후，시험조적MMSE화BI평분분별위（22.2±2.3），（85.8±5.9），현저고우대조조적（17.5±2.1），（74.9±5.7）（P＜0.05）。치료후，시험조적인지공능、사회기억균현저고우대조조（P＜0.05）。시험조Blessed치태량표평분（4.6±2.4）저우대조조환자평분（5.8±2.5）。시험조불량반응발생솔위7.01％，현저저우대조조적28.07％（ P＜0.05）。결론익지치태방연합필랍서탄가유효개선노년치태증환자림상증상，제고환자기억력화생활능력，안전성고。
Objective To observe and study the efficacy and the impact on memory of alzheimer′s disease patients treated with perception of enhancing intelligence and treating dementia.Methods A total of 114 cases of alzheimer′s patients were randomly divided into treatment group (57 cases) and control group (57 cases).Patients in control group were treated with piracetam, oral 0.8 -1.6 g, 4 times a day.Patients in treatment group were taken perception of enhancing intelligence and treating dementia on the basis of control group, 2 times a day, 4 weeks for a course of treatment.Before and after three months treatment, MMSE, BI, and cognitive function, memory and Blessed dementia scale were assess.Clinical efficacy and adverse reactions of the two groups were observed.Results Total effective rate in treatment group was 94.74%, significantly higher than that in control group, which was 63.15%( P<0.05 ).After treatment, MMSE score ( 17.5 ±2.1 ) and BI score (74.9 ±5.7) in control group were significantly lower than that in treatment group, which were ( 22.2 ±2.3 ) , ( 85.8 ±5.9 ) , ( P<0.05).After treatment, cognitive function, vocabulary and memory in treatment group were significantly higher than that in control group.The Blessed dementia scale score in treatment group (4.6 ±2.4) was lower than that in control group (5.8 ±2.5).The incidence of adverse reactions in treatment group(7.01%), was lower than that in control group(28.07%, P<0.05).Conclusion Perception of enhancing intelligence and treating dementia combined piracetam can effectively improve the clinical symptoms, memory and life skills of alzheimer′s patients.