中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
The Chinese Journal of Clinical Pharmacology
2015年
15期
1484-1486
,共3页
雷公藤多苷%糖皮质激素%免疫球蛋白A肾病%淋巴细胞亚群%临床疗效
雷公籐多苷%糖皮質激素%免疫毬蛋白A腎病%淋巴細胞亞群%臨床療效
뢰공등다감%당피질격소%면역구단백A신병%림파세포아군%림상료효
tripterygium glycosides%glucocorticoid%IgA nephropathy%lymphocyte subset%clinical efficacy
目的：评价雷公藤多苷与小剂量糖皮质激素治疗免疫球蛋白A肾病的临床疗效及其对患者T淋巴细胞亚群的影响。方法入选免疫球蛋白A肾病患者86例（试验组）和健康者91例（对照组）作为研究对象。试验组口服氯沙坦钾50 mg · d－1， qd ＋醋酸泼尼松片0.5 mg · kg－1， qd ＋雷公藤多苷片1 mg· kg－1，tid，疗程为3个月。分别检测患者治疗前后及健康查体人员血清T淋巴细胞Th1／Th2细胞因子及免疫球蛋白A的临床疗效。结果治疗前，试验组干扰素（IFN）－γ和白细胞介素（IL）－2显著低于对照组（P＜0.05）；IL－4和IL－10显著高于对照组（ P＜0.05）。治疗3个月后，试验组临床总有效率为91.8％。治疗后，试验组患者尿素氮、尿酸和血肌酸酐均较治疗前显著降低（P＜0.05）；IFN－γ及IL－2较治疗前显著升高（P＜0.05），IL－4及IL－10较治疗前显著降低（ P＜0.05）。结论雷公藤多苷治疗免疫球蛋白A肾病的临床疗效确切，对患者T淋巴细胞亚群失衡有一定的调节作用。
目的：評價雷公籐多苷與小劑量糖皮質激素治療免疫毬蛋白A腎病的臨床療效及其對患者T淋巴細胞亞群的影響。方法入選免疫毬蛋白A腎病患者86例（試驗組）和健康者91例（對照組）作為研究對象。試驗組口服氯沙坦鉀50 mg · d－1， qd ＋醋痠潑尼鬆片0.5 mg · kg－1， qd ＋雷公籐多苷片1 mg· kg－1，tid，療程為3箇月。分彆檢測患者治療前後及健康查體人員血清T淋巴細胞Th1／Th2細胞因子及免疫毬蛋白A的臨床療效。結果治療前，試驗組榦擾素（IFN）－γ和白細胞介素（IL）－2顯著低于對照組（P＜0.05）；IL－4和IL－10顯著高于對照組（ P＜0.05）。治療3箇月後，試驗組臨床總有效率為91.8％。治療後，試驗組患者尿素氮、尿痠和血肌痠酐均較治療前顯著降低（P＜0.05）；IFN－γ及IL－2較治療前顯著升高（P＜0.05），IL－4及IL－10較治療前顯著降低（ P＜0.05）。結論雷公籐多苷治療免疫毬蛋白A腎病的臨床療效確切，對患者T淋巴細胞亞群失衡有一定的調節作用。
목적：평개뢰공등다감여소제량당피질격소치료면역구단백A신병적림상료효급기대환자T림파세포아군적영향。방법입선면역구단백A신병환자86례（시험조）화건강자91례（대조조）작위연구대상。시험조구복록사탄갑50 mg · d－1， qd ＋작산발니송편0.5 mg · kg－1， qd ＋뢰공등다감편1 mg· kg－1，tid，료정위3개월。분별검측환자치료전후급건강사체인원혈청T림파세포Th1／Th2세포인자급면역구단백A적림상료효。결과치료전，시험조간우소（IFN）－γ화백세포개소（IL）－2현저저우대조조（P＜0.05）；IL－4화IL－10현저고우대조조（ P＜0.05）。치료3개월후，시험조림상총유효솔위91.8％。치료후，시험조환자뇨소담、뇨산화혈기산항균교치료전현저강저（P＜0.05）；IFN－γ급IL－2교치료전현저승고（P＜0.05），IL－4급IL－10교치료전현저강저（ P＜0.05）。결론뢰공등다감치료면역구단백A신병적림상료효학절，대환자T림파세포아군실형유일정적조절작용。
Objective To evaluate the clinical efficacy of tripterygium glycosides and small dose of glucocorticoid on IgA nephropathy and its influence on T lymph cells.Methods A total of 86 patients with IgA nephropathy were enrolled as the treatment group and 91 cases of healthy controls were recruited as the control group.Patients in the treatment group were administered with cozaar 50 mg· kg -1 ,qd orally plus predni-sone 0.5 mg · kg -1 , qd orally plus tripterygium glycosides 1 mg · kg -1 tid orally for 3 months.The data of clinical efficacy in treatment group and Th1/Th2 before and after treatment in two groups were recorded and compared.Results The serum level of interferon( IFN) -γand inter-leukin ( IL)-2 in treatment group were significantly lower than those in control group ( P<0.05 ).And the serum level of IL-4 and IL-10 were significantly higher than those in control group ( P<0.05 ).After 3 months treatment, the total effective rate was 91.8%in treatment group.The serum level of urea nitrogen, uric acid, and creatinine were signifi-cantly decreased after treatment ( P<0.05).After treatment, the serum level of IFN-γand IL-2 was significantly elevated ( P<0.05 ) , and the level of IL-4 and IL-10 was significantly decreased ( P<0.05 ).Conclusion Tripterygium glycosides is effective in treatment of IgA nephropathy, which could also improve the T lymph cell immune system.
