中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
The Chinese Journal of Clinical Pharmacology
2015年
15期
1480-1483
,共4页
抑肝散%小儿多动症%家庭环境%生活习惯%环境毒物
抑肝散%小兒多動癥%傢庭環境%生活習慣%環境毒物
억간산%소인다동증%가정배경%생활습관%배경독물
Yi-gan-san%ADHD%family environment%habit and custom%environmental toxicology
目的：探讨注意力缺陷多动障碍（ ADHD）的临床相关因素，评价抑肝散治疗小儿多动症的临床效果。方法入选120例ADHD患儿作为研究对象，健康儿童120例作为对照组，通过问卷调查形式评价家庭环境、儿童生活习惯、儿童环境毒物接触情况对ADHD的影响。另选取患儿中证属脾虚肝亢者75例，其中试验组38例，对照组37例，对照组给予单纯行为治疗，每周3次；试验组在对照组治疗基础上，口服加味抑肝散150 mL，一日2次，疗程为8周，分别于入组前，治疗后4，8周行中医证候积分评定和疗效判断。结果父母学历低于初中、采取责罚教育方式、家庭月收入低于每月3000元、单亲或隔代抚养家庭、人工喂养、父母为独生子女均为发生ADHD的危险因素。作息不规律、缺乏爱好、睡眠紊乱、易食零食，接触增塑剂（ DEHP ）次数越多及玩手机次数越频繁更易患ADHD。试验组控显率为52．63％，总有效率为86.84％；对照组控显率为24.32％，总有效率为43.24％，试验组疗效优于对照组（ P＜0.01）。治疗8周后，2组中医证候积分均显著降低（P＜0.01），试验组治疗后中医证候积分低于对照组，其改善程度更显著。结论 ADHD发生与家庭环境、儿童生活习惯及接触环境毒物有一定关系；抑肝散治疗脾虚肝亢型ADHD疗效确切。
目的：探討註意力缺陷多動障礙（ ADHD）的臨床相關因素，評價抑肝散治療小兒多動癥的臨床效果。方法入選120例ADHD患兒作為研究對象，健康兒童120例作為對照組，通過問捲調查形式評價傢庭環境、兒童生活習慣、兒童環境毒物接觸情況對ADHD的影響。另選取患兒中證屬脾虛肝亢者75例，其中試驗組38例，對照組37例，對照組給予單純行為治療，每週3次；試驗組在對照組治療基礎上，口服加味抑肝散150 mL，一日2次，療程為8週，分彆于入組前，治療後4，8週行中醫證候積分評定和療效判斷。結果父母學歷低于初中、採取責罰教育方式、傢庭月收入低于每月3000元、單親或隔代撫養傢庭、人工餵養、父母為獨生子女均為髮生ADHD的危險因素。作息不規律、缺乏愛好、睡眠紊亂、易食零食，接觸增塑劑（ DEHP ）次數越多及玩手機次數越頻繁更易患ADHD。試驗組控顯率為52．63％，總有效率為86.84％；對照組控顯率為24.32％，總有效率為43.24％，試驗組療效優于對照組（ P＜0.01）。治療8週後，2組中醫證候積分均顯著降低（P＜0.01），試驗組治療後中醫證候積分低于對照組，其改善程度更顯著。結論 ADHD髮生與傢庭環境、兒童生活習慣及接觸環境毒物有一定關繫；抑肝散治療脾虛肝亢型ADHD療效確切。
목적：탐토주의력결함다동장애（ ADHD）적림상상관인소，평개억간산치료소인다동증적림상효과。방법입선120례ADHD환인작위연구대상，건강인동120례작위대조조，통과문권조사형식평개가정배경、인동생활습관、인동배경독물접촉정황대ADHD적영향。령선취환인중증속비허간항자75례，기중시험조38례，대조조37례，대조조급여단순행위치료，매주3차；시험조재대조조치료기출상，구복가미억간산150 mL，일일2차，료정위8주，분별우입조전，치료후4，8주행중의증후적분평정화료효판단。결과부모학력저우초중、채취책벌교육방식、가정월수입저우매월3000원、단친혹격대무양가정、인공위양、부모위독생자녀균위발생ADHD적위험인소。작식불규률、결핍애호、수면문란、역식령식，접촉증소제（ DEHP ）차수월다급완수궤차수월빈번경역환ADHD。시험조공현솔위52．63％，총유효솔위86.84％；대조조공현솔위24.32％，총유효솔위43.24％，시험조료효우우대조조（ P＜0.01）。치료8주후，2조중의증후적분균현저강저（P＜0.01），시험조치료후중의증후적분저우대조조，기개선정도경현저。결론 ADHD발생여가정배경、인동생활습관급접촉배경독물유일정관계；억간산치료비허간항형ADHD료효학절。
Objective To explore the main influence factors of attention deficit hyperactivity disorder ( ADHD) and evaluate the clinical effect of Yi-gan-san modified.Methods Questionnaire survey consisting of home environment, living habits and exposure to environmental toxicant was used to investigate and evaluate children in the two groups, one of them was the study group with 120 cases of ADHD children, and the other was the control group with 120 cases of healthy children.A total of 75 cases with the pi-xu-gan-kang type were found among the ADHD children, and they were randomly divided into 2 groups:the experimental group ( n =38 ) , using drug therapy of Yi -gan -san modified ( 150 mL, twice a day ) and behavioral therapy (3 times a week);the control group, using behavioral therapy alone.The treatment lasted for all 8 weeks.The data of the line integral of traditional Chinese medicine symp-tom assessment was used to evaluate the curative effect before treatment and 4, 8 weeks after treatment.Results The survey found that the family environment such as low education level of parents, parenting methods, family income less than three thousand yuan each month, parenting and feeding patterns, whether both parents were the only child in the family were significantly associated with the occurrence of ADHD.We also found the exposure to DEHP, children′s rest hobbies, sleep habits, eclipse snack times and playing phone were significantly re-lated with the occurrence of ADHD.The CR of the treatment group was 52.63% and the total effective rate was 86.84%, and there was 24.32%and 43.24%in the control group respectively.The TCM syndrome score between the two groups had significant statistical significance ( P<0.01 ) , and the curative effect of the treatment group was better than that in the control group.The TCM syndrome score were significantly lowered after 8 weeks of treatment in the two groups (P<0.01).Conclusion The family environment, lifestyle and children′exposure to environmental toxicants were susceptible to the occurrence of ADHD.Using Yi-gan-san modified intervention for the treatment of ADHD is effective.
