CAJ | 학술논문

目的：评价依布利特与普罗帕酮转复心房颤动的临床疗效及安全性。方法入选心房颤动患者66例，并随机分为试验组31例和对照组35例。试验组10 min内静脉注射依布利特1 mg，对照组10 min内静脉注射普罗帕酮70 mg，2组如未转复成功可于给药结束后再重复给药一次。观察2组患者用药后90 min内窦性心律转复成功率、转复时间及不良反应发生率。结果试验组用药90 min内转复窦性心律的成功率为74.2％，对照组转复成功率为51.4％。试验组中位转复时间为20.5 min，显著低于对照组的25.2 min（P＜0.05）。试验组与对照组不良反应发生率分别为29.0％和25.7％，差异无统计学意义（ P＞0.05）。结论依布利特转复心房颤动成功率较高，转复时间较短。
목적：평개의포리특여보라파동전복심방전동적림상료효급안전성。방법입선심방전동환자66례，병수궤분위시험조31례화대조조35례。시험조10 min내정맥주사의포리특1 mg，대조조10 min내정맥주사보라파동70 mg，2조여미전복성공가우급약결속후재중복급약일차。관찰2조환자용약후90 min내두성심률전복성공솔、전복시간급불량반응발생솔。결과시험조용약90 min내전복두성심률적성공솔위74.2％，대조조전복성공솔위51.4％。시험조중위전복시간위20.5 min，현저저우대조조적25.2 min（P＜0.05）。시험조여대조조불량반응발생솔분별위29.0％화25.7％，차이무통계학의의（ P＞0.05）。결론의포리특전복심방전동성공솔교고，전복시간교단。
Objective To evaluate the clinical efficacy and safety of ibutilide and propafenone in the treatment of patients with atrial fibrilla-tion.Methods A total of 66 patients with atrial fibrillation were included in this study.Of the recruited 66 subjects, 31 cases ( experiment group ) received ibutilide 1 mg by intravenous injection within 10 min and other 35 cases ( control group) received propafenone 70 mg by intravenous injection within 10 min.The treatment procedure were done again if the atrial fibrillation still existed after administration.The successful rate and adverse reactions were recorded in the two groups.Results The successful rate was 74.2% in experiment group and 51.4%in control group with statistical difference ( P<0.05 ).The median time of cardioversion was 20.5 min for experiment group and 25.2 min in control group with significant difference ( P<0.05 ).The rate of adverse reactions were 29.0% and 25.7% in the treatment and control group, respectively without statistical difference ( P >0.05 ).Conclusion The successful rate of ibutilide in the treatment of patients with atrial fibrillation is relative higher with short period of time for success.