CAJ | 학술논문

目的：探讨新生儿起病的克隆恩病的诊断和治疗。方法回顾性分析1例新生儿起病的克隆恩病患儿的临床资料。结果男性患儿，生后5 d即出现间断发热、口腔溃疡、皮肤脓疱疹、间断腹泻伴白细胞增高，先后诊断为“脓毒血症、细菌性肠炎、白塞病、免疫缺陷病、营养性贫血、牛奶不耐受、炎症性肠病”，直肠黏膜病理诊断及术后肠管病理检查确诊为克隆恩病，于8月龄死于肠穿孔。结论对于新生儿起反复口腔溃疡、皮肤脓疱疹、肛周溃疡和发热的患儿，应及早进行结肠镜检查以明确诊断。
목적：탐토신생인기병적극륭은병적진단화치료。방법회고성분석1례신생인기병적극륭은병환인적림상자료。결과남성환인，생후5 d즉출현간단발열、구강궤양、피부농포진、간단복사반백세포증고，선후진단위“농독혈증、세균성장염、백새병、면역결함병、영양성빈혈、우내불내수、염증성장병”，직장점막병리진단급술후장관병리검사학진위극륭은병，우8월령사우장천공。결론대우신생인기반복구강궤양、피부농포진、항주궤양화발열적환인，응급조진행결장경검사이명학진단。
ObjectiveTo investigate the diagnosis and treatment of Crohn disease in neonates.Methods The clinical data of one case of neonatal onset Crohn disease were retrospectively analyzed.Results Male infant had intermittent fever, recurrent oral ulcers, skin impetigo and intermittent diarrhea with increased WBC counts from ifve days after birth. He had been diagnosed as sepsis, bacterial enteritis, Behcet's disease, immunodeifciency disease, nutritional anemia, milk intolerance, and inlfammatory bowel disease. Finally he was diagnosed as Crohn disease by rectal mucosa pathology and postoperative bowel pa-thology. He died of intestinal perforation on 8 months.ConclusionsThe infants who have recurrent oral ulcers, skin impetigo, perianal ulcers and fever from neonatal should undergo colonoscopy for the diagnosis.