CAJ | 학술논문

背景：内固定后四肢骨折不愈合是骨折后最常见的并发症之一，影响骨折愈合的因素较多，近年来有学者研究发现血清瘦素可能参与骨折愈合过程中多种代谢的调节。目的：分析内固定手术治疗四肢长管状骨骨折，患者血清瘦素水平变化与骨折愈合的关系。方法：选择四肢长管状骨骨折的患者60例，根据内固定后8个月骨折愈合情况分为骨折愈合组30例和骨折不愈合组30例，另取30例健康志愿者为正常对照组。分别于内固定前后抽取患者外周静脉血，采用双抗体夹心酶联免疫吸附试验(ELISA)检测血清瘦素水平的变化。结果与结论：骨折愈合组和骨折不愈合组患者内固定前后血清瘦素水平均高于正常对照组(P<0.05)；骨折愈合组高于不愈合组(P <0.05)。骨折愈合组内固定前后血清瘦素水平差异无显著性意义；骨折不愈合组内固定后血清瘦素水平显著高于内固定前(P<0.05)。结果提示瘦素可能在骨折愈合过程有一定影响。
배경：내고정후사지골절불유합시골절후최상견적병발증지일，영향골절유합적인소교다，근년래유학자연구발현혈청수소가능삼여골절유합과정중다충대사적조절。목적：분석내고정수술치료사지장관상골골절，환자혈청수소수평변화여골절유합적관계。방법：선택사지장관상골골절적환자60례，근거내고정후8개월골절유합정황분위골절유합조30례화골절불유합조30례，령취30례건강지원자위정상대조조。분별우내고정전후추취환자외주정맥혈，채용쌍항체협심매련면역흡부시험(ELISA)검측혈청수소수평적변화。결과여결론：골절유합조화골절불유합조환자내고정전후혈청수소수평균고우정상대조조(P<0.05)；골절유합조고우불유합조(P <0.05)。골절유합조내고정전후혈청수소수평차이무현저성의의；골절불유합조내고정후혈청수소수평현저고우내고정전(P<0.05)。결과제시수소가능재골절유합과정유일정영향。
BACKGROUND:After internal fixation, limb fracture nonunion is the most common complication. Many factors affect fracture healing, but in recent years researchers have found that serum leptin may be involved in the process of fracture healing to regulate a variety of metabolisms. OBJECTIVE:To analyze the relationship between the changes of serum leptin and fracture healing in patients with long tubular fracture of the limbs after internal fixation. METHODS:Sixty patients with long tubular bone fracture who underwent internal fixation treatment were selected, and divided into two groups, union group (n=30) and nonunion group (n=30), according to the degree of fracture healing at 8 months after operation. Another 30 healthy volunteers served as normal control group. Peripheral blood samples were extracted before and after internal fixation to detect the changes in serum leptin levels using ELISA. RESULTS AND CONCLUSION:Preoperative serum leptin level was higher in the union group and nonunion group than the normal control group as wel as higher in the union group than the nonunion group (P < 0.05). There was no difference in the serum leptin levels in the union group before and after operation, but the nonunion group had a higher preoperative serum leptin level than the postoperative level. These findings indicate that the serum leptin may have an influence on fracture healing.