检验医学与临床
檢驗醫學與臨床
검험의학여림상
Laboratory Medicine and Clinic
2015年
18期
2746-2747
,共2页
病毒性脑膜炎%化脓性脑膜炎%降钙素原%C反应蛋白%中性粒细胞CD64
病毒性腦膜炎%化膿性腦膜炎%降鈣素原%C反應蛋白%中性粒細胞CD64
병독성뇌막염%화농성뇌막염%강개소원%C반응단백%중성립세포CD64
viral meningitis%purulent meningitis%procalcitonin%C-reactive protein%neutrophil CD64
目的：分析脑脊液及血清降钙素原（PCT ）、中性粒细胞 CD64、C 反应蛋白（CRP）在小儿不同病原体感染脑膜炎中的鉴别价值，并探讨3种检测方法对患儿治疗及预后监测的可行性。方法选择123例脑膜炎患儿，并根据鉴别诊断分为化脓性脑膜炎（化脑组）65例、病毒性脑膜炎（病脑组）58例，同时选取非中枢神经系统感染性患儿60例作为对照（对照组）。在患儿入院24 h 内及治疗一段时间后，抽取其静脉血及脑脊液进行血清 PCT 、CRP 、中性粒细胞 CD64测定，分析各组患儿对3项指标在急性期和恢复期的变化及阳性率。结果3项检测结果在发病初期对化脑组及病脑组的比较均有明显的鉴别意义，各组间差异有统计学意义（P＜0．05）；在各组急性期与恢复期的鉴别检测中，CRP 在化脑组及病脑组鉴别差异有统计学意义（P＜0．05），而 CD64对于检测化脑组差异有统计学意义（P＜0．05），但对病脑组的表达水平与对照组比较差异无统计学意义；两组脑膜炎患儿的阳性率比较， PCT 检测差异有统计学意义，而 CRP 则无显著差异。结论 PCT 在治疗前观察及预后检测均有效，对鉴别小儿化脓性脑膜炎和病毒性脑膜炎有重要的参考价值，优于 CRP 的检测结果。 CD64对小儿化脓性脑膜炎的检测有重要意义，可作为有效指标在临床中推广使用。
目的：分析腦脊液及血清降鈣素原（PCT ）、中性粒細胞 CD64、C 反應蛋白（CRP）在小兒不同病原體感染腦膜炎中的鑒彆價值，併探討3種檢測方法對患兒治療及預後鑑測的可行性。方法選擇123例腦膜炎患兒，併根據鑒彆診斷分為化膿性腦膜炎（化腦組）65例、病毒性腦膜炎（病腦組）58例，同時選取非中樞神經繫統感染性患兒60例作為對照（對照組）。在患兒入院24 h 內及治療一段時間後，抽取其靜脈血及腦脊液進行血清 PCT 、CRP 、中性粒細胞 CD64測定，分析各組患兒對3項指標在急性期和恢複期的變化及暘性率。結果3項檢測結果在髮病初期對化腦組及病腦組的比較均有明顯的鑒彆意義，各組間差異有統計學意義（P＜0．05）；在各組急性期與恢複期的鑒彆檢測中，CRP 在化腦組及病腦組鑒彆差異有統計學意義（P＜0．05），而 CD64對于檢測化腦組差異有統計學意義（P＜0．05），但對病腦組的錶達水平與對照組比較差異無統計學意義；兩組腦膜炎患兒的暘性率比較， PCT 檢測差異有統計學意義，而 CRP 則無顯著差異。結論 PCT 在治療前觀察及預後檢測均有效，對鑒彆小兒化膿性腦膜炎和病毒性腦膜炎有重要的參攷價值，優于 CRP 的檢測結果。 CD64對小兒化膿性腦膜炎的檢測有重要意義，可作為有效指標在臨床中推廣使用。
목적：분석뇌척액급혈청강개소원（PCT ）、중성립세포 CD64、C 반응단백（CRP）재소인불동병원체감염뇌막염중적감별개치，병탐토3충검측방법대환인치료급예후감측적가행성。방법선택123례뇌막염환인，병근거감별진단분위화농성뇌막염（화뇌조）65례、병독성뇌막염（병뇌조）58례，동시선취비중추신경계통감염성환인60례작위대조（대조조）。재환인입원24 h 내급치료일단시간후，추취기정맥혈급뇌척액진행혈청 PCT 、CRP 、중성립세포 CD64측정，분석각조환인대3항지표재급성기화회복기적변화급양성솔。결과3항검측결과재발병초기대화뇌조급병뇌조적비교균유명현적감별의의，각조간차이유통계학의의（P＜0．05）；재각조급성기여회복기적감별검측중，CRP 재화뇌조급병뇌조감별차이유통계학의의（P＜0．05），이 CD64대우검측화뇌조차이유통계학의의（P＜0．05），단대병뇌조적표체수평여대조조비교차이무통계학의의；량조뇌막염환인적양성솔비교， PCT 검측차이유통계학의의，이 CRP 칙무현저차이。결론 PCT 재치료전관찰급예후검측균유효，대감별소인화농성뇌막염화병독성뇌막염유중요적삼고개치，우우 CRP 적검측결과。 CD64대소인화농성뇌막염적검측유중요의의，가작위유효지표재림상중추엄사용。
Objective To analyze the identification value of cerebrospinal fluid(CSF) and serum procalcitonin (PCT ) ,neutrophil CD64 and C‐reactive protein(CRP) in children meningitis infected by different pathogens and to explore the feasibility of three methods for monitoring the treatment and prognosis .Methods 123 children cases of meningitis ,including purulent meningitis(PM group ,65 cases) and viral meningitis(VM group58 cases) according to the differential diagnosis .At the same time ,60 children patients with non‐central nervous system infection were se‐lected as the healthy control group (control group) .Serum and CSF were sampled for detecting PCT ,neutrophil CD64 and CRP within 24 ho after admission and after a time of treatment .The change and positive rate of these 3 in‐dexes in the acute stage and recovery stage were analyzed .Results The detection results of these 3 indexes in the early onset had obvious identification significance in the PM group and the VM group ,the differences among groups were statistically significant (P< 0 .05) ;in the identification detection in the acute and recovery stages of various groups ,the identification difference of CRP between the PM group and the VM group had statistical significance(P<0 .05) ;acute phase and recovery phase differential detection ,CRP has statistical difference between the PM group and disease group(P< 0 .05) ,the difference of CD64 had statistical significance for the detection of the PM group(P <0 .05) ,but the expression level of the VM group group had no statistical difference compared with the control group ;in the comparison of the positive rate in the PM group and the VM group ,the difference of PCT detection had statis‐tical significance ,while CRP had no significant difference .Conclusion PCT is effective for the observation before treatment and prognosis detection ,has an important reference value in the differentiation diagnosis of PM and VM ,is better than the CRP detection result .CD64 has important significance for the detection of PM in children ,can be used as an effective index in clinical promoting use .
