CAJ | 학술논문

目的：探讨淀粉样蛋白 A 在慢性阻塞性肺疾病急性加重期的表达，为临床提供参考。方法选择百色市人民医院2013年2月至2014年5月收治的80例慢性阻塞性肺疾病急性加重期患者。根据分级将80例患者分成 A 组、B 组，每组各40例。随机选取同时期在百色市人民医院体检健康的60例患者，纳为 C 组，观察检查结果。结果与 C 组相比，稳定期及加重期患者在血清淀粉样蛋白 A 、C 反应蛋白（CRP）方面对比后，差异有统计学意义（t＝6．113、6．292，7．093、8．393，P＜0．05）。与稳定期患者相比，加重期患者的血清淀粉样蛋白 A 、CRP 方面对比后，差异有统计学意义（t＝6．458、8．652，P ＜0．05）。对于 A 组患者，血清淀粉样蛋白 A 、CRP 的敏感度分别为70．0％、75．0％，特异度分别为60．0％、42．5％，而对于 B 组患者，其敏感度和特异度分别为82．5％、67．5％，90．0％、67．5％，其水平更优。与患者没有脓性痰且痰培养结果阴性相比，有脓性痰或者痰培养结果阳性患者的血清淀粉样蛋白 A 与 CRP 等方面，差异有统计学意义（t ＝6．492、7．083，P ＜0．05）。结论检测血清淀粉样蛋白 A水平对患者的病情程度具有重要的指导意义。同时可以帮助患者指导抗菌药物的使用，值得临床推广。
목적：탐토정분양단백 A 재만성조새성폐질병급성가중기적표체，위림상제공삼고。방법선택백색시인민의원2013년2월지2014년5월수치적80례만성조새성폐질병급성가중기환자。근거분급장80례환자분성 A 조、B 조，매조각40례。수궤선취동시기재백색시인민의원체검건강적60례환자，납위 C 조，관찰검사결과。결과여 C 조상비，은정기급가중기환자재혈청정분양단백 A 、C 반응단백（CRP）방면대비후，차이유통계학의의（t＝6．113、6．292，7．093、8．393，P＜0．05）。여은정기환자상비，가중기환자적혈청정분양단백 A 、CRP 방면대비후，차이유통계학의의（t＝6．458、8．652，P ＜0．05）。대우 A 조환자，혈청정분양단백 A 、CRP 적민감도분별위70．0％、75．0％，특이도분별위60．0％、42．5％，이대우 B 조환자，기민감도화특이도분별위82．5％、67．5％，90．0％、67．5％，기수평경우。여환자몰유농성담차담배양결과음성상비，유농성담혹자담배양결과양성환자적혈청정분양단백 A 여 CRP 등방면，차이유통계학의의（t ＝6．492、7．083，P ＜0．05）。결론검측혈청정분양단백 A수평대환자적병정정도구유중요적지도의의。동시가이방조환자지도항균약물적사용，치득림상추엄。
Objective To investigate the expression of amyloid A in the acute exacerbation of chronic obstruc‐tive pulmonary disease(AECOPD) .Methods 80 patients with AECOPD in our hospital from February 2013 to May 2014 were chosen and divided into the group A and B according to the stages ,40 cases in each group .Contemporane‐ous 40 cases of healthy physical examination in our hospital were randomly selected as the group C .The amyloid A and CRP levels were detected and the results were observed .Results Compared with the group C ,the serum amyloid A and CRP levels had statistical differences between the stable stage and exacerbation stage(t= 6 .113 ,6 .292 ,7 .093 , 8 .393 ,P< 0 .05) .Compared with the stable stage ,serum amyloid A and CRP levels in the exacerbation stage had sta‐tistical difference (t= 6 .458 ,8 .652 ,P < 0 .05) .For the group A ,sensitivities of serum amyloid A and CRP were 70 .0% and 75 .0% respectively ,their specificities were 60 .0% and 42 .5% respectively ,while for the group B ,the sensitivity and specificity were 82 .5% ,67 .5% and 90 .0% ,67 .5% respectively and the levels were much better .Ser‐um amyloid A and CRP levels in the patients with purulent sputum and sputum cultures positive had statistical differ‐ences compared with the patients without purulent sputum and sputum cultures positive(t= 6 .492 ,7 .083 ,P< 0 .05) . Conclusion The serum amyloid A level has an important guiding significance for the disease severity ,at the same time can help the patients to guide the use of antibacterial drugs ,and is worthy of being clinically promoted .