CAJ | 학술논문

目的：利用数据挖掘方法探讨非酒精性脂肪性肝病（NAFLD）的证候规律及治疗组方用药特点。方法在中国知网、维普、万方数据库中以及手工检索2000—2013年有关 NAFLD 中医证候及治疗的临床研究文献。将符合要求的文献建立数据库，由研究人员对文献进行筛选和数据提取，进行频数分析以及关联规则分析。结果124篇文献中涉及44个证型，将44个证型分解后共得到证候要素16个，其中病位证素6个，病性证素10个；纳入文献使用的156张处方中，用药168味，共1687频次；经关联规则分析得到治疗 NAFLD 的常用药物配伍。结论痰、湿、瘀、气滞是NAFLD 发病的关键，病位在肝、脾，证型以实证和虚实夹杂证为主，攻补兼施是 NAFLD 的基本治则。
목적：이용수거알굴방법탐토비주정성지방성간병（NAFLD）적증후규률급치료조방용약특점。방법재중국지망、유보、만방수거고중이급수공검색2000—2013년유관 NAFLD 중의증후급치료적림상연구문헌。장부합요구적문헌건립수거고，유연구인원대문헌진행사선화수거제취，진행빈수분석이급관련규칙분석。결과124편문헌중섭급44개증형，장44개증형분해후공득도증후요소16개，기중병위증소6개，병성증소10개；납입문헌사용적156장처방중，용약168미，공1687빈차；경관련규칙분석득도치료 NAFLD 적상용약물배오。결론담、습、어、기체시NAFLD 발병적관건，병위재간、비，증형이실증화허실협잡증위주，공보겸시시 NAFLD 적기본치칙。
Objective To reveal the rules of TCMsyndromes and prescription of non-alcoholic fatty liver disease(NAFLD)by using data mining methods.Methods After retrieving clinical trials of CNKI,VIP and Wanfang database related to TCM treatment and syndromes of NAFLD,besides manual searching from 2000 to 2013,the database was established.Then the literature was screened and extracted for anal-ysis of frequency and relevance principles.Results Altogether 44 TCMsyndrome patterns were involved in 124 citations included.By disintegration of the 44 syndromes,16 syndrome factors appeared including 6 factors of disease location and 10 factors of disease nature.There were 168 Chinese medicinal herbs with the total frequency of 1 687 used in 156 prescriptions.By using relevance principle analysis,the common compatibility of crude herbs used on treatment of NAFLD was listed.Conclusion The key fac-tors of NAFLD were phlegm,dampness,blood stasis and qi stagnation,and the disease locations were at liver and spleen.Pathogenesis were mainly syndrome of excess and syndrome of intermingled deficiency and excess.So the foundamental principle of treatment of NAFLD was reinforcement combined with elimi-nation.